Reactions 1364 - 13 Aug 2011

★ SOxcarbazepine

Acute bilateral anterior uveitis (first report) andhypersensitivity: case report

A 34-year-old woman developed acute bilateral anterioruveitis and hypersensitivity while receiving oxcarbazepine[Trileptal] for epilepsy.

The woman presented at an emergency department withpain and a 1-week history of blurred vision in both eyes.She was receiving treatment with oxcarbazepine for herepileptic episodes [dosage, route and duration of treatmentto reaction onset not stated]. Examination revealed visualacuities of one unit in both eyes, as well as a cellular tyndallof +2 and keratic precipitates. One month prior topresentation, her oxcarbazepine dose had been increased.At that time, she developed skin lesions on her lower limbs.Following a skin biopsy, leukocytoclastic vasculitis withmoderate eosinophilia was reported.

Oxcarbazepine was switched to topiramate. Thewoman’s skin lesions rapidly improved upon treatmentwith topical steroids. She also received ocular topicalsteroids and cyclopentolate, after which, her ocularinflammation completely resolved in both eyes.

Author comment: "Considering the criteria applied by theWHO (the Naranjo [algorithm]) to assess the cause of adversereaction to a drug, our patient exhibited a score of 7. Thisincludes her in the probable allergic reaction category."Gros-Otero J, et al. Bilateral acute anterior uveitis and anticonvulsanthypersensitivity syndrome. Archivos de la Sociedad Espanola de Oftalmologia 85:376-7, No. 11, Nov 2010 - Spain 803058695

» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of uveitisassociated with oxcarbazepine. The WHO ADR databasecontained three reports of uveitis associated withoxcarbazepine.

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Reactions 13 Aug 2011 No. 13640114-9954/10/1364-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved