Reactions 1479, p25-26 - 23 Nov 2013

SOxcarbazepine

Complete atrioventricular block in an elderlypatient: case report

A 67-year-old woman developed complete atrioventricular(AV) block while receiving oxcarbazepine for partial seizures.

The woman presented to an emergency service with severeheadaches and fatigue. Her symptoms had been intermittentsince she started receiving oxcarbazepine 300mg twice daily2 years earlier [route and time to reaction onset not stated]. Onadmission, cardiac examination found bradycardia; followingan ECG, she was transferred to a cardiology clinic with adiagnosis of complete atrioventricular block.

The woman received a temporary pacemaker. ECG foundgrade 1 diastolic dysfunction, and oxcarbazepine waswithdrawn; she started receiving levetiracetam. Three dayslater, she developed 2:1 AV block followed by normal sinusrhythm. No arrhythmia was detected on 24-hour Holtermonitoring. The pacemaker was removed, and she wasdischarged. No bradycardia or conduction disorders werefound during follow-up.

Author comment: "[A]nother reason of complete AV blockmight be the effect of [oxcarbazepine] on potassiumchannels."Karabag T, et al. A rare complication during oxcarbazepine use, completeatrioventricular block: Case report. Turkiye Klinikleri Cardiovascular Sciences 25:26-28, No. 1, 10 Oct 2013. Available from: URL: http://www.turkiyeklinikleri.com/article/en-a-rare-complication-during-oxcarbazepine-use-complete-atrioventricular-block-case-report-66107.html - Turkey 803095847

1

Reactions 23 Nov 2013 No. 14790114-9954/13/1479-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved