Reactions 1386 - 28 Jan 2012

Carbamazepine

Lichenoid eruption: case reportA 39-year-old man developed a lichenoid eruption of his

oral mucosa after treatment with carbamazepine.The man presented with a 6-month history of pain and

burning in his mouth. He had been receivingcarbamazepine [dosage and route not stated] andfluoxetine in the past 12 months to control alcoholwithdrawal syndrome. Examination revealed papules andwhitish plaques on his buccal mucosa with erythematousand ulcerated areas. He also had hyperpigmented areas, aswell as white plaques and streaks on his upper and lowerlips. Histopathology of a mucosal biopsy was consistentwith a diagnosis of oral lichen planus.

The man received topical clobetasol propionate for15 days, after whicih his lesions improved markedly. Adetailed history then revealed that his medication had beenwithdrawn 3 weeks earlier. Topical corticosteroids werediscontinued. Ten months later, his lesions showed furtherimprovement, and a biopsy taken from a previouslyaffected area showed a mild diffuse inflammatory infiltrateand hyperkeratosis.

Author comment: "The significant improvement of theoral lesions suggested the diagnosis of [lichenoid drugreaction] induced by carbamazepine."Artico G, et al. Lichenoid reaction to carbamazepine in the oral mucosa - Casereport. Anais Brasileiros de Dermatologia 86 (Suppl. 1): 152-155, No. 41, Aug2011 - Brazil 803066199

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Reactions 28 Jan 2012 No. 13860114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved