Carbamazepine
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Reactions 1386 - 28 Jan 2012 Carbamazepine Lichenoid eruption: case report A 39-year-old man developed a lichenoid eruption of his oral mucosa after treatment with carbamazepine. The man presented with a 6-month history of pain and burning in his mouth. He had been receiving carbamazepine [dosage and route not stated] and fluoxetine in the past 12 months to control alcohol withdrawal syndrome. Examination revealed papules and whitish plaques on his buccal mucosa with erythematous and ulcerated areas. He also had hyperpigmented areas, as well as white plaques and streaks on his upper and lower lips. Histopathology of a mucosal biopsy was consistent with a diagnosis of oral lichen planus. The man received topical clobetasol propionate for 15 days, after whicih his lesions improved markedly. A detailed history then revealed that his medication had been withdrawn 3 weeks earlier. Topical corticosteroids were discontinued. Ten months later, his lesions showed further improvement, and a biopsy taken from a previously affected area showed a mild diffuse inflammatory infiltrate and hyperkeratosis. Author comment: "The significant improvement of the oral lesions suggested the diagnosis of [lichenoid drug reaction] induced by carbamazepine." Artico G, et al. Lichenoid reaction to carbamazepine in the oral mucosa - Case report. Anais Brasileiros de Dermatologia 86 (Suppl. 1): 152-155, No. 41, Aug 2011 - Brazil 803066199 1 Reactions 28 Jan 2012 No. 1386 0114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1386 - 28 Jan 2012
Carbamazepine
Lichenoid eruption: case reportA 39-year-old man developed a lichenoid eruption of his
oral mucosa after treatment with carbamazepine.The man presented with a 6-month history of pain and
burning in his mouth. He had been receivingcarbamazepine [dosage and route not stated] andfluoxetine in the past 12 months to control alcoholwithdrawal syndrome. Examination revealed papules andwhitish plaques on his buccal mucosa with erythematousand ulcerated areas. He also had hyperpigmented areas, aswell as white plaques and streaks on his upper and lowerlips. Histopathology of a mucosal biopsy was consistentwith a diagnosis of oral lichen planus.
The man received topical clobetasol propionate for15 days, after whicih his lesions improved markedly. Adetailed history then revealed that his medication had beenwithdrawn 3 weeks earlier. Topical corticosteroids werediscontinued. Ten months later, his lesions showed furtherimprovement, and a biopsy taken from a previouslyaffected area showed a mild diffuse inflammatory infiltrateand hyperkeratosis.
Author comment: "The significant improvement of theoral lesions suggested the diagnosis of [lichenoid drugreaction] induced by carbamazepine."Artico G, et al. Lichenoid reaction to carbamazepine in the oral mucosa - Casereport. Anais Brasileiros de Dermatologia 86 (Suppl. 1): 152-155, No. 41, Aug2011 - Brazil 803066199
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Reactions 28 Jan 2012 No. 13860114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
