Reactions 1420 - 22 Sep 2012

SAntineoplastics

Neutropenia and thrombocytopenia in a neonate:case report

A 16-day-old boy with a congenital Askin tumourdeveloped haematological toxicities during chemotherapy[routes, dosages, durations of treatment to reactions onsetand outcomes not stated].

The tumour had been diagnosed at 37 weeks’ gestation.The baby was born at term via Caesarean delivery,weighing 3.390kg. Following complete gross resection ofthe lesion, he received isofosamide, carboplatin, etoposide,cyclophosphamide, doxorubicin and vincristine (ICE-CAV).Doses were adjusted for age and weight considering asquare metre equivalent to 30kg and a further dosereduction of 25–30% for a weight less than 5kg. Duringchemotherapy, he developed grade 3/4 neutropenia and/orthrombocytopenia. He achieved complete remission andwas disease-free at last follow-up.

Author comment: "[T]he ICE-CAV regimen that wasadministered with the chemotherapy dose adjusted forweight was well tolerated with manageable short- and long-term toxicities."Crocoli A, et al. Congenital Askin tumor with favorable outcome: Case report andreview of the literature. Journal of Pediatric Surgery 47: 1440-1444, No. 7, Jul2012. Available from: URL: http://dx.doi.org/10.1016/j.jpedsurg.2012.02.028 -Italy 803077388

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Reactions 22 Sep 2012 No. 14200114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved