Warsaw Ochota CampusWarsaw Ochota Campus

BBioioIInfonfoMMededResearch CentreResearch Centre

Jerzy Duszyński

Marcin Szumowski

Plan of the Plan of the presentationpresentation

Ochota Campus IntroductionOchota Campus Introduction Building human potential and Building human potential and infrastructureinfrastructure Core competencies and growth Core competencies and growth opportunitiesopportunities Taking the next stepTaking the next step Synergies with EU, national, regional Synergies with EU, national, regional initiativesinitiatives The Ochota Campus of 2020 – benefits The Ochota Campus of 2020 – benefits for the region, Poland and Europefor the region, Poland and Europe

Faculty of Chemistry Warsaw University

Banacha Clinical Hospital

The Medical University of Warsaw

Faculty of Biology Warsaw University

Faculty of Geology Warsaw University

Faculty of Mathematics Warsaw University

Nencki Institute of Experimental Biology, PAS

Institute of Geophysics Warsaw University

Interdisciplinary Centre for Mathematical and Computational Modelling (ICM), UW

Prepared by: Marcin Szumowski, IBD PAN

Institute of Biocybernetics and Biomedical Engineering, PAS

International Institute of Molecular and Cell Biology

Interdisciplinary Centre for Mathematical and Computational Modelling (ICM), UW

Institute of Biochemistry and Biophysics, PAS

TheThe Ochota Ochota CampusCampus**

14 scientific institutions in one square kilometre: Polish Academy of Sciences (PAS): Nencki Institute of Experimental Biology (NIEB), Institutes of Biochemistry and Biophysics (IBB), Biocybernetics and Biomedical Engineering (IBBE) and Medical Research Centre (MRC).

International Institute of Molecular and Cellular Biology (IIMCB) Warsaw University (UW): Faculties of biology, chemistry, physics (geophysics), geology, mathematics and Interdisciplinary Centre for Mathematical and Computational Modelling (ICM), Heavy Ion Laboratory (HIL) The Medical University of Warsaw and the largest clinical hospital in Poland.

* Ochota is one of the central districts of Warsaw

The Ochota Campus in The Ochota Campus in numbersnumbers

Total employment > 5Total employment > 55500; 00; research scientists > 1research scientists > 15500 (~50% in bio-00 (~50% in bio-sciences);sciences); PhD students > PhD students > 101000 (~50% in bio-sciences)00 (~50% in bio-sciences)

Total annual turnover > Total annual turnover > 550 million euro0 million euro Total assets > 1Total assets > 1550 million euro0 million euro Advanced Technology Centre in Advanced Technology Centre in Biotechnology, Biotechnology,

Bioinformatics and Biomedicine Bioinformatics and Biomedicine (BioInfoMed) (BioInfoMed)

Equipment and facilitiesEquipment and facilitiesRecent and pending(2005 – 2006)investment projectsin excess of € 15 MEU Structural (75%)and National (25%)Funds

Building human Building human capitalcapital

In In one one decade decade ((1980-19901980-1990)), ~700 scientists from , ~700 scientists from the Ochota Campus emigrated to USA, France, UK, the Ochota Campus emigrated to USA, France, UK, GermanyGermany……

Many of them are eager and willing to returnMany of them are eager and willing to return Their standard requirements include:Their standard requirements include:

1.1. independent laboratory with 3 or more staff independent laboratory with 3 or more staff (including 2 (including 2 or more PhD students)or more PhD students)

2.2. sstart up funds of 100 000 - 500 000 €tart up funds of 100 000 - 500 000 €3.3. 50 -100 m50 -100 m2 of lab space of lab space4.4. eeasy access to top-level core research facilitiesasy access to top-level core research facilities

2-4 are currently insufficient or lacking in the Ochota 2-4 are currently insufficient or lacking in the Ochota CampusCampus

Area of the Ochota Campus - 1945

Nencki Institute

Faculty of Chemistry UW

Warsaw Medical University Hospital

Faculty of Biology UW

Faculty of Mathematics UW

Faculty of Geology UW Heavy Ion Laboratory UW

The Ochota Campus in 2000

„ … There are great gaps in the research areas covered by truly international laboratories. In the area of the Life Sciences, with which I am familiar, I would suggest that it would be of major benefit to establish an Institute for Neurobiology (perhaps in Poland), an Institute for Microbiology (perhaps in the Czech Republic) and an Institute for Plant Biology (perhaps in Hungary). If all three were based on the highly successful EMBL model, then such franchising could have the same powerful impact both scientifically and regionally.”

From an assessment paper by Frank Gannon, Director of the European Molecular Biology Organization (EMBO)

Neuroscience is one of the key competence areas of the Ochota Research Campus

Taking the next stepTaking the next stepOchota Campus of Ochota Campus of

20202020

Spending on Biomedical Research as % of total Research Funding (stimulating the modern knowledge based economy):- Australia 66%- USA 55%- EU average 25%- Poland < 20% The Ochota Campus has the intellectual potential, concentration of resources and demonstrated scientific excellence to reverse this unfavourable ratio for BioMed funding. Our research focuses on: - molecular biology, bio-medicine and neurosciences - high-power computing and modelling (bioinformatics) - protein structure research - preclinical and clinical research (diseases of the nervous system, vascular patophysiology, cancerogenesis, etc.)

Modern Core Modern Core CompetenciesCompetencies

Synergy with ESFRISynergy with ESFRI** Priorities Priorities

BMS (BioMedSci) ESFRI working groups will most likely support the following projects: Structural Biology Network (centres equipped with X-ray, NMR, PET, electron microscopy etc.) Archiving & phenotyping mouse and rat central facilities European network for advanced clinical research Biobanks

Emerging embryonic projects: - systematic biology - imaging biological structure

CAMPUS OCHOTA HAS VERY STRONG COMPETENCE IN ALL THESE AREAS

* ESFRI – European Strategy For Research Infrastructure

Synergies with other activitiesSynergies with other activities International level

– roughly 1/3 of Poland’s participation in FP6 First Priority can be accounted for by projects realised by the Ochota Campus institutions– involvement in several EU GRID projects– 8 EU Centres of Excellence

National Level– Advanced Technology Centre BioInfoMed– seven national competence centres in priority technology areas– several investment projects funded from structural funds

Regional level– development of a nearby Warsaw Technological Park (City of Warsaw initiative)

Innovation through technology transfer from scientific institutions to industry requires industry pull (market demand) and scientific push (innovative ideas, technologies). Warsaw area accounts for nearly 40% of all R&D and higher education institutions in Poland. Warsaw has also the highest concentration of high-tech industry (e.g., nearly 40% of telecom industries are located in the region).

Ochota Ochota Campus Campus of of 20202020 - - a visiona vision

an internationally recognized EU scientific research an internationally recognized EU scientific research centre with an international steering committee, over centre with an international steering committee, over 2000 scientists, over 1500 PhD students and many 2000 scientists, over 1500 PhD students and many satellite institutions satellite institutions one of the largest interdisciplinary bioscience centres one of the largest interdisciplinary bioscience centres and the highest concentration of scientific potential in and the highest concentration of scientific potential in CEECEE a leading centre in neurobiology and a leading centre in neurobiology and neurodegeneration neurodegeneration world leading expertise in protein modelling and world leading expertise in protein modelling and structurestructure national biobanks and associated patient history national biobanks and associated patient history databases of hereditary cancer and rare diseases databases of hereditary cancer and rare diseases regionally unique diagnostic capabilities (e.g., genetic regionally unique diagnostic capabilities (e.g., genetic screening, bio-medical imaging, fMRI, PET, etc.)screening, bio-medical imaging, fMRI, PET, etc.) balanced funding from multiple international and balanced funding from multiple international and national sources including the private sectornational sources including the private sector

Core facility Core facility developmentdevelopment

requires a multi-stakeholder approach: scientific community, industry, local governments and administration as well as funding agencies at all levels

strategic resource allocation from ESFRI, European Investment Bank, Structural Funds (national and regional levels), national funds, industry (~200 M euro)

Ochota Research Campus of 2020 will capitalize on the existing scientific excellence and core competencies adding modern infrastructure, core facilities and international programmes to join the European elite of leading biomedical research centres.