Oxcarbazepine/topiramate
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Reactions 1407 - 23 Jun 2012 S Oxcarbazepine/topiramate Multiple fetal anomalies following in utero exposure: case report Multiple fetal anomalies occurred at 17 weeks’ gestation [sex not stated] following in utero exposure to oxcarbazepine and topiramate. The fetus’ mother, a 32-year-old woman, was continuously receiving topiramate 100mg and oxcarbazepine 300mg following a brain operation 2 years previously [frequencies and routes not stated]. She was admitted at 17 weeks’ gestation, and ultrasound of the fetus revealed severe oligohydramnios, pericardiac fluid collection, cardiomegaly, lower extremity limb defects, a cleft lip and palate, an absent right kidney and a dysplastic left kidney. She underwent a cordocentesis procedure, and abortion was medically induced. Autopsy of the fetus additionally revealed absence of the left lower extremity, an absent right foot, an absent right forearm, absent radius and four digit of the left arm, adrenal gland aplasia, and hypoplasia of the urinary bladder and rectum. Author comment: "Here we present a case with multiple anomalies in association with the use of combined therapy of topiramate and oxcarbazepine." Uludag S, et al. Multiple fetal anomalies in association with topiramate and oxcarbezepine treatment. Fetal and Pediatric Pathology 31: 154-158, No. 3, Jun 2012. Available from: URL: http://dx.doi.org/10.3109/15513815.2012.659378 - Turkey 803072419 1 Reactions 23 Jun 2012 No. 1407 0114-9954/10/1407-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine/topiramate
Reactions 1407 - 23 Jun 2012
SOxcarbazepine/topiramate
Multiple fetal anomalies following in uteroexposure: case report
Multiple fetal anomalies occurred at 17 weeks’ gestation[sex not stated] following in utero exposure tooxcarbazepine and topiramate.
The fetus’ mother, a 32-year-old woman, wascontinuously receiving topiramate 100mg andoxcarbazepine 300mg following a brain operation 2 yearspreviously [frequencies and routes not stated]. She wasadmitted at 17 weeks’ gestation, and ultrasound of thefetus revealed severe oligohydramnios, pericardiac fluidcollection, cardiomegaly, lower extremity limb defects, acleft lip and palate, an absent right kidney and a dysplasticleft kidney. She underwent a cordocentesis procedure, andabortion was medically induced. Autopsy of the fetusadditionally revealed absence of the left lower extremity, anabsent right foot, an absent right forearm, absent radiusand four digit of the left arm, adrenal gland aplasia, andhypoplasia of the urinary bladder and rectum.
Author comment: "Here we present a case with multipleanomalies in association with the use of combined therapy oftopiramate and oxcarbazepine."Uludag S, et al. Multiple fetal anomalies in association with topiramate andoxcarbezepine treatment. Fetal and Pediatric Pathology 31: 154-158, No. 3, Jun2012. Available from: URL: http://dx.doi.org/10.3109/15513815.2012.659378 -Turkey 803072419
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Reactions 23 Jun 2012 No. 14070114-9954/10/1407-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
