Oxcarbazepine
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Reactions 441 - 6 Mar 1993 Oxcarbazepine Skin eruption with cross-sensitivity to carbamazepine: 3 case reports A serious skin reaction occurred in 3 men (aged 68, 21 and 24 years, respectively) after receiving 2-3 doses of oral oxcarbazepine 300mg for epilepsy; no other signs of hypersensitivity were present. The patients had all experienced a serious skin reaction to carbamazepine approximately 6-10 years prior to this episode. Oxcarbazepine was discontinued in all patients with a subsequent resolution of the skin reaction. The 68-year-old man was treated with antihistamines and Alpha-Keri (Rm) lotion. Oxcarbazepine, believed to cause fewer adverse effects than carbamazepine, had been initiated in the patients on an individual patient usage (IPU) provision because of inadequate seizure control with other anticonvulsants. Author comment: ‘Physicians should use caution when choosing to use OCBZ (oxcarbazepine) as a CBZ (carbamazepine) substitute in patients with a previous history of serious skin reaction to CBZ.’ Beran RG. Cross-reactive skin eruption with both carbamazepine and oxcarbazepine. Epilepsia 34: 163-165, Jan-Feb 1993 - Australia 800183468 1 Reactions 6 Mar 1993 No. 441 0114-9954/10/0441-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 441 - 6 Mar 1993
Oxcarbazepine
Skin eruption with cross-sensitivity tocarbamazepine: 3 case reports
A serious skin reaction occurred in 3 men (aged 68, 21 and24 years, respectively) after receiving 2-3 doses of oraloxcarbazepine 300mg for epilepsy; no other signs ofhypersensitivity were present. The patients had all experienceda serious skin reaction to carbamazepine approximately 6-10years prior to this episode. Oxcarbazepine was discontinued inall patients with a subsequent resolution of the skin reaction.The 68-year-old man was treated with antihistamines andAlpha-Keri (Rm) lotion. Oxcarbazepine, believed to causefewer adverse effects than carbamazepine, had been initiatedin the patients on an individual patient usage (IPU) provisionbecause of inadequate seizure control with otheranticonvulsants.
Author comment: ‘Physicians should use caution whenchoosing to use OCBZ (oxcarbazepine) as a CBZ(carbamazepine) substitute in patients with a previous historyof serious skin reaction to CBZ.’Beran RG. Cross-reactive skin eruption with both carbamazepine andoxcarbazepine. Epilepsia 34: 163-165, Jan-Feb 1993 - Australia 800183468
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Reactions 6 Mar 1993 No. 4410114-9954/10/0441-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
