Oxcarbazepine
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Reactions 1333 - 8 Jan 2011 Oxcarbazepine Erythema multiforme following radiotherapy: 4 case reports Three men and one woman with epilepsy secondary to cerebral high-grade glioma, aged 25–75 years, developed erythema multiforme (EM) during treatment with oxcarbazepine and radiotherapy [times to reaction onsets not stated]. Two patients started receiving oxcarbazepine 900 mg/day, and two started treatment at a dosage of 1200 mg/day [routes not stated]. Brain radiotherapy (total dose 60 Gy) was subsequently initiated in all patients, and was associated with temozolomide in three patients. All patients presented with major pruritic skin reactions 2–14 days after commencement of radiotherapy. The rash was characterised by papules, macules and boils, which spread from the scalp to face, shoulders, and trunk; all patients also had moderate fever. EM secondary to concomitant treatment with radiotherapy and oxcarbazepine was diagnosed. Oxcarbazepine was discontinued after 1 or 2 months of therapy in all patients. Two patients required additional treatment with chlorphenamine and ebastine. EM gradually resolved in all patients. Maschio M, et al. Rash in four patients with brain tumor-related epilepsy in monotherapy with oxcarbazepine, during radiotherapy. Journal of Neurology 257: 1939-1940, No. 11, Nov 2010. Available from: URL: http://dx.doi.org/10.1007/ s00415-010-5637-x - Italy 803046706 1 Reactions 8 Jan 2011 No. 1333 0114-9954/10/1333-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Oxcarbazepine
Reactions 1333 - 8 Jan 2011
Oxcarbazepine
Erythema multiforme following radiotherapy:4 case reports
Three men and one woman with epilepsy secondary tocerebral high-grade glioma, aged 25–75 years, developederythema multiforme (EM) during treatment withoxcarbazepine and radiotherapy [times to reaction onsetsnot stated].
Two patients started receiving oxcarbazepine 900mg/day, and two started treatment at a dosage of1200 mg/day [routes not stated]. Brain radiotherapy (totaldose 60 Gy) was subsequently initiated in all patients, andwas associated with temozolomide in three patients. Allpatients presented with major pruritic skin reactions2–14 days after commencement of radiotherapy. The rashwas characterised by papules, macules and boils, whichspread from the scalp to face, shoulders, and trunk; allpatients also had moderate fever. EM secondary toconcomitant treatment with radiotherapy andoxcarbazepine was diagnosed.
Oxcarbazepine was discontinued after 1 or 2 months oftherapy in all patients. Two patients required additionaltreatment with chlorphenamine and ebastine. EM graduallyresolved in all patients.Maschio M, et al. Rash in four patients with brain tumor-related epilepsy inmonotherapy with oxcarbazepine, during radiotherapy. Journal of Neurology 257:1939-1940, No. 11, Nov 2010. Available from: URL: http://dx.doi.org/10.1007/s00415-010-5637-x - Italy 803046706
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Reactions 8 Jan 2011 No. 13330114-9954/10/1333-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
