Oxcarbazepine
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Reactions 1321 - 2 Oct 2010 S Oxcarbazepine Tardive dyskinesia in a child: case report An 8-year-old girl was diagnosed with epilepsy and began oxcarbazepine treatment. She underwent 1 week of therapy with oxcarbazepine 15 mg/kg/day [route not stated], with the dosage subsequently increased to 30 mg/kg/day. Three days after receiving the full dose, she was admitted to the emergency service with movement abnormalities. Physical examination revealed trismus, deviation of the eyes, tongue protrusion and lateral flexion of the trunk. Oxcarbazepine was withdrawn after the girl was diagnosed with tardive dyskinesia. She received single- dose IV diazepam and was subsequently treated with oral diphenhydramine for 2 weeks. In 3 days, her symptoms resolved. Author comment: "Use of the Naranjo ADR Probability Scale indicated a probable (the score was 6) relationship between tardive dyskinesia and [oxcarbazepine] therapy in this patient." Herguner MO, et al. Oxcarbazepine-induced tardive dyskinesia: A rare adverse reaction. Journal of Pediatric Neurosciences 5: 85-86, Jan-Jun 2010. Available from: URL: http://dx.doi.org/10.4103/1817-1745.66664 - Turkey 803040322 1 Reactions 2 Oct 2010 No. 1321 0114-9954/10/1321-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Oxcarbazepine
Reactions 1321 - 2 Oct 2010
SOxcarbazepine
Tardive dyskinesia in a child: case reportAn 8-year-old girl was diagnosed with epilepsy and
began oxcarbazepine treatment. She underwent 1 week oftherapy with oxcarbazepine 15 mg/kg/day [route notstated], with the dosage subsequently increased to30 mg/kg/day. Three days after receiving the full dose, shewas admitted to the emergency service with movementabnormalities. Physical examination revealed trismus,deviation of the eyes, tongue protrusion and lateral flexionof the trunk. Oxcarbazepine was withdrawn after the girlwas diagnosed with tardive dyskinesia. She received single-dose IV diazepam and was subsequently treated with oraldiphenhydramine for 2 weeks. In 3 days, her symptomsresolved.
Author comment: "Use of the Naranjo ADR ProbabilityScale indicated a probable (the score was 6) relationshipbetween tardive dyskinesia and [oxcarbazepine] therapy inthis patient."Herguner MO, et al. Oxcarbazepine-induced tardive dyskinesia: A rare adversereaction. Journal of Pediatric Neurosciences 5: 85-86, Jan-Jun 2010. Availablefrom: URL: http://dx.doi.org/10.4103/1817-1745.66664 - Turkey 803040322
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Reactions 2 Oct 2010 No. 13210114-9954/10/1321-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
