Oxcarbazepine
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Reactions 1086 - 28 Jan 2006 ★ Oxcarbazepine First report of migraine exacerbation during cross- over from carbamazepine: 3 case reports Three women with epilepsy developed migraines while switching from carbamazepine to oxcarbazepine. A 33-year-old woman, with a history of sumatriptan- responsive migraines, was switched from carbamazepine 1200 mg/day to oxcarbazepine 2100 mg/day. During cross- over, she experienced a refractory migraine, with a pounding headache, nausea and vomiting, lasting 4 days. Oxcarbazepine was discontinued and carbamazepine reintroduced, with resolution of her migraine. A 38-year-old woman, with a history of mild migraines, was switched from carbamazepine 1600 mg/day to oxcarbazepine 2400 mg/day. During cross-over, she developed a pounding headache and vomiting. Her migraine was refractory to treatment, but resolved after discontinuation of oxcarbazepine and reintroduction of carbamazepine. A 30-year-old woman, with a history of migraines treated with dipyrone, caffeine and isometheptene, was switched from carbamazepine 1200 mg/day to oxcarbazepine 1800 mg/day. After 7 days, she developed a migraine that persisted for 4 days and resolved after oxcarbazepine discontinuation and carbamazepine reintroduction. Amaral V, et al. Status migranosus induced by oxcarbazepine in three women with epilepsy and migraine. Epilepsia 46 (Suppl. 6): 282, 2005 - Brazil 801025073 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of migraine associated with oxcarbazepine. The WHO Adverse Drug Reactions database ten reports of migraine associated with oxcarbazepine. 1 Reactions 28 Jan 2006 No. 1086 0114-9954/10/1086-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1086 - 28 Jan 2006
★Oxcarbazepine
First report of migraine exacerbation during cross-over from carbamazepine: 3 case reports
Three women with epilepsy developed migraines whileswitching from carbamazepine to oxcarbazepine.
A 33-year-old woman, with a history of sumatriptan-responsive migraines, was switched from carbamazepine1200 mg/day to oxcarbazepine 2100 mg/day. During cross-over, she experienced a refractory migraine, with a poundingheadache, nausea and vomiting, lasting 4 days. Oxcarbazepinewas discontinued and carbamazepine reintroduced, withresolution of her migraine.
A 38-year-old woman, with a history of mild migraines, wasswitched from carbamazepine 1600 mg/day to oxcarbazepine2400 mg/day. During cross-over, she developed a poundingheadache and vomiting. Her migraine was refractory totreatment, but resolved after discontinuation of oxcarbazepineand reintroduction of carbamazepine.
A 30-year-old woman, with a history of migraines treatedwith dipyrone, caffeine and isometheptene, was switchedfrom carbamazepine 1200 mg/day to oxcarbazepine1800 mg/day. After 7 days, she developed a migraine thatpersisted for 4 days and resolved after oxcarbazepinediscontinuation and carbamazepine reintroduction.Amaral V, et al. Status migranosus induced by oxcarbazepine in three women withepilepsy and migraine. Epilepsia 46 (Suppl. 6): 282, 2005 - Brazil 801025073
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of migraine associated withoxcarbazepine. The WHO Adverse Drug Reactions database tenreports of migraine associated with oxcarbazepine.
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Reactions 28 Jan 2006 No. 10860114-9954/10/1086-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
