Chlorzoxazone
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Reactions 1502, p13 - 24 May 2014 ★ Chlorzoxazone First report of abdominal discomfort: 5 case reports An observational study of ten patients who received compassionate-use chlorzoxazone for downbeat nystagmus identified four women and one man, 59–78 years of age, who developed abdominal discomfort. The patients received oral chlorzoxazone 500mg tablets three times a day for 1 or 2 weeks, with two doses on the first day of treatment. Abdominal discomfort occurred, after 1 week in one of the patients [durations of treatment to reaction onset not all stated]. Blood tests results were normal. Chlorzoxazone was withdrawn in one patient [not all outcomes stated]. Author comment: "With our dosage, 50% of patients already reported abdominal discomfort, which was probably due to the high initial dose. Perhaps patients would tolerate the drug better with a slower titration." Feil K, et al. Effect of chlorzoxazone in patients with downbeat nystagmus: A pilot trial. Neurology 81: 1152-1158, No. 13, 24 Sep 2013 - Germany 803103491 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of abdominal discomfort associated with chlorzoxazone. The WHO ADR database contained one report of abdominal discomfort associated with chlorzoxazone. 1 Reactions 24 May 2014 No. 1502 0114-9954/14/1502-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
Transcript of Chlorzoxazone
Reactions 1502, p13 - 24 May 2014
★Chlorzoxazone
First report of abdominal discomfort: 5 case reportsAn observational study of ten patients who received
compassionate-use chlorzoxazone for downbeat nystagmusidentified four women and one man, 59–78 years of age, whodeveloped abdominal discomfort. The patients received oralchlorzoxazone 500mg tablets three times a day for 1 or2 weeks, with two doses on the first day of treatment.Abdominal discomfort occurred, after 1 week in one of thepatients [durations of treatment to reaction onset not allstated]. Blood tests results were normal. Chlorzoxazone waswithdrawn in one patient [not all outcomes stated].
Author comment: "With our dosage, 50% of patientsalready reported abdominal discomfort, which was probablydue to the high initial dose. Perhaps patients would toleratethe drug better with a slower titration."Feil K, et al. Effect of chlorzoxazone in patients with downbeat nystagmus: A pilottrial. Neurology 81: 1152-1158, No. 13, 24 Sep 2013 - Germany 803103491
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of abdominaldiscomfort associated with chlorzoxazone. The WHO ADRdatabase contained one report of abdominal discomfortassociated with chlorzoxazone.
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Reactions 24 May 2014 No. 15020114-9954/14/1502-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved
