Carbamazepine overdose
1
Reactions 424 - 24 Oct 1992 ★ Carbamazepine overdose First report of hyponatraemia in a child: case report Hyponatraemia occurred in a 2.5-year-old boy after he ingested a massive overdose of carbamazepine. The boy was given 3.3% dextrose and 0.3% normal saline for over 6 hours prior to admission. Seven hours after ingestion of the overdose, his serum carbamazepine concentration was 129 micromol/L (therapeutic level 17-50 micromol/L). Following admission, the child received 5.0% dextrose and 0.9% saline for 7 hours, followed by 5% dextrose and 0.2% saline (duration of treatment unclear). Serum sodium and potassium levels measured 9 hours after carbamazepine ingestion were 131 mmol/L and 4.2 mmol/L, respectively. 19 hours after the carbamazepine overdose, the boy had a generalised tonic- clonic seizure lasting 30 seconds, and at this time his serum sodium level was 121 mmol/L and serum potassium level was 3 mmol/L. Author comment: ‘Acute intoxication with carbamazepine has not been reported previously to cause symptomatic hyponatremia ... Physicians caring for carbamazepine overdoses should be alert to the possibility of a drop in sodium levels’ Edge W, et al. Serum sodium and carbamazepine overdose. Journal of Toxicology - Clinical Toxicology 30: 479-480, Sep 1992 - Canada 800160926 1 Reactions 24 Oct 1992 No. 424 0114-9954/10/0424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
-
Upload
truongdiep -
Category
Documents
-
view
216 -
download
2
Transcript of Carbamazepine overdose
Reactions 424 - 24 Oct 1992
★Carbamazepine overdose
First report of hyponatraemia in a child: case reportHyponatraemia occurred in a 2.5-year-old boy after he
ingested a massive overdose of carbamazepine. The boy wasgiven 3.3% dextrose and 0.3% normal saline for over 6 hoursprior to admission. Seven hours after ingestion of theoverdose, his serum carbamazepine concentration was 129micromol/L (therapeutic level 17-50 micromol/L). Followingadmission, the child received 5.0% dextrose and 0.9% salinefor 7 hours, followed by 5% dextrose and 0.2% saline (durationof treatment unclear). Serum sodium and potassium levelsmeasured 9 hours after carbamazepine ingestion were 131mmol/L and 4.2 mmol/L, respectively. 19 hours after thecarbamazepine overdose, the boy had a generalised tonic-clonic seizure lasting 30 seconds, and at this time his serumsodium level was 121 mmol/L and serum potassium level was3 mmol/L.
Author comment: ‘Acute intoxication with carbamazepinehas not been reported previously to cause symptomatichyponatremia ... Physicians caring for carbamazepineoverdoses should be alert to the possibility of a drop in sodiumlevels’Edge W, et al. Serum sodium and carbamazepine overdose. Journal of Toxicology- Clinical Toxicology 30: 479-480, Sep 1992 - Canada 800160926
1
Reactions 24 Oct 1992 No. 4240114-9954/10/0424-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
