Carbamazepine overdose
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Reactions 401 - 16 May 1992 Carbamazepine overdose Neurological manifestations: 5 case reports Five children, aged 21 months to 14 years, were admitted after acute or chronic carbamazepine overdose. Presenting symptoms included coma, lethargy, nystagmus and respiratory depression. Peak carbamazepine concentrations ranged from 22-60 mcg/ml (therapeutic range 0.5-20 mcg/ml). Four of the children received multiple doses of activated charcoal and neurological status normalised in all of the children 9-36 hours postadmission Editorial comment: In 3 cases, the quantities of carbamazepine ingested were unknown. The other 2 patients developed neurological symptoms while receiving carbamazepine 100mg tid and 1 g/day, respectively. Wason S, et al. Carbamazepine overdose - the effects of multiple dose activated charcoal. Journal of Toxicology - Clinical Toxicology 30: 39-48, Mar 1992 - USA 800129748 » Editorial comment: In 3 cases, the quantities of carbamazepine ingested were unknown. The other 2 patients developed neurological symptoms while receiving carbamazepine 100mg tid and 1 g/day, respectively. 1 Reactions 16 May 1992 No. 401 0114-9954/10/0401-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine overdose
Reactions 401 - 16 May 1992
Carbamazepine overdose
Neurological manifestations: 5 case reportsFive children, aged 21 months to 14 years, were admitted
after acute or chronic carbamazepine overdose. Presentingsymptoms included coma, lethargy, nystagmus andrespiratory depression. Peak carbamazepine concentrationsranged from 22-60 mcg/ml (therapeutic range 0.5-20 mcg/ml).Four of the children received multiple doses of activatedcharcoal and neurological status normalised in all of thechildren 9-36 hours postadmission Editorial comment: In3 cases, the quantities of carbamazepine ingested wereunknown. The other 2 patients developed neurologicalsymptoms while receiving carbamazepine 100mg tid and 1g/day, respectively.Wason S, et al. Carbamazepine overdose - the effects of multiple dose activatedcharcoal. Journal of Toxicology - Clinical Toxicology 30: 39-48, Mar 1992 -USA 800129748
» Editorial comment: In 3 cases, the quantities ofcarbamazepine ingested were unknown. Theother 2 patients developed neurological symptoms whilereceivingcarbamazepine 100mg tid and 1 g/day, respectively.
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Reactions 16 May 1992 No. 4010114-9954/10/0401-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
