Carbamazepine overdose
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Reactions 1365 - 20 Aug 2011 O S Carbamazepine overdose Unconsciousness and respiratory insufficiency: case report A 48-year-old man was admitted, unconscious and with respiratory insufficiency, after taking an overdose of carbamazepine. The man had been receiving carbamazepine 400mg twice daily for 10 years for a psychiatric illness; it was assumed to have been prescribed as a mood stabiliser. He had taken an unknown amount of carbamazepine, thought to be 150–200 tablets of carbamazepine 400mg. On arrival at an emergency department, he was unconscious and unresponsive, with respiratory insufficiency [time to reaction onset not stated]. The man was intubated and ventilated, and received gastric lavage and charcoal on admission. His serum carbamazepine level was 25.6 µg/mL. He remained unresponsive after 24 hours, so haemodialysis was initiated. After 2 sessions, he improved, and was weaned and extubated within the following 2 days. After a further dialysis session, his carbamazepine level was within the therapeutic range, and, 5 days after admission, he was discharged in a stable condition. Ram Prabahar M, et al. Successful treatment of carbamazepine poisoning with hemodialysis: A case report and review of the literature. Hemodialysis International 15: 407-411, No. 3, Jul 2011. Available from: URL: http:// dx.doi.org/10.1111/j.1542-4758.2011.00559.x - India 803058984 1 Reactions 20 Aug 2011 No. 1365 0114-9954/10/1365-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine overdose
Reactions 1365 - 20 Aug 2011
O SCarbamazepine overdose
Unconsciousness and respiratory insufficiency:case report
A 48-year-old man was admitted, unconscious and withrespiratory insufficiency, after taking an overdose ofcarbamazepine.
The man had been receiving carbamazepine 400mgtwice daily for 10 years for a psychiatric illness; it wasassumed to have been prescribed as a mood stabiliser. Hehad taken an unknown amount of carbamazepine, thoughtto be 150–200 tablets of carbamazepine 400mg. On arrivalat an emergency department, he was unconscious andunresponsive, with respiratory insufficiency [time toreaction onset not stated].
The man was intubated and ventilated, and receivedgastric lavage and charcoal on admission. His serumcarbamazepine level was 25.6 µg/mL. He remainedunresponsive after 24 hours, so haemodialysis wasinitiated. After 2 sessions, he improved, and was weanedand extubated within the following 2 days. After a furtherdialysis session, his carbamazepine level was within thetherapeutic range, and, 5 days after admission, he wasdischarged in a stable condition.Ram Prabahar M, et al. Successful treatment of carbamazepine poisoning withhemodialysis: A case report and review of the literature. HemodialysisInternational 15: 407-411, No. 3, Jul 2011. Available from: URL: http://dx.doi.org/10.1111/j.1542-4758.2011.00559.x - India 803058984
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Reactions 20 Aug 2011 No. 13650114-9954/10/1365-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
