Carbamazepine
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Reactions 1043 - 19 Mar 2005 ★ S Carbamazepine First report of tonic-clonic seizures: case report A 20-year-old man with autism spectrum disorders experienced new-onset tonic-clonic seizures during treatment with carbamazepine. The man started treatment with carbamazepine 600 mg/day (serum concentration 8.5 µg/mL) for disruptive behaviours. He experienced a generalised tonic-clonic seizure approximately 2 months later, and three tonic-clonic convulsions were observed on 1 day 3 months later; an EEG showed bilateral and diffuse spike and waveforms. Carbamazepine was switched to valproic acid and the man’s seizures resolved. Valproic acid was tapered to discontinuation after 12 months and, during 10 months’ follow-up, no seizures or EEG abnormalities were observed. Monji A, et al. Carbamazepine may trigger new-onset epileptic seizures in an individual with autism spectrum disorders: a case report. European Psychiatry 19: 322-323, No. 5, Aug 2004 - Japan 807218793 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of tonic-clonic seizures associated with carbamazepine. The WHO Adverse Drug Reactions database contained 171 reports of grand mal convulsions associated with carbamazepine. 1 Reactions 19 Mar 2005 No. 1043 0114-9954/10/1043-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1043 - 19 Mar 2005
★ SCarbamazepine
First report of tonic-clonic seizures: case reportA 20-year-old man with autism spectrum disorders
experienced new-onset tonic-clonic seizures during treatmentwith carbamazepine.
The man started treatment with carbamazepine 600 mg/day(serum concentration 8.5 µg/mL) for disruptive behaviours. Heexperienced a generalised tonic-clonic seizure approximately2 months later, and three tonic-clonic convulsions wereobserved on 1 day 3 months later; an EEG showed bilateraland diffuse spike and waveforms.
Carbamazepine was switched to valproic acid and the man’sseizures resolved. Valproic acid was tapered todiscontinuation after 12 months and, during 10 months’follow-up, no seizures or EEG abnormalities were observed.Monji A, et al. Carbamazepine may trigger new-onset epileptic seizures in anindividual with autism spectrum disorders: a case report. European Psychiatry 19:322-323, No. 5, Aug 2004 - Japan 807218793
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of tonic-clonic seizuresassociated with carbamazepine. The WHO Adverse DrugReactions database contained 171 reports of grand malconvulsions associated with carbamazepine.
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Reactions 19 Mar 2005 No. 10430114-9954/10/1043-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
