Carbamazepine
1
Reactions 531 - 10 Dec 1994 Carbamazepine Cholangitis in an elderly patient: case report Cholangitis in an elderly man was clearly caused by carbamazepine therapy. Carbamazepine 200mg bid had been started to treat partial seizures. However, after 4 weeks’ therapy the 66-year-old man was admitted with a temperature of 39°C and mild upper abdominal pain. His serum liver enzyme levels were as follows: alkaline phosphatase 628 U/L (normal 73–207), glutamic oxalacetic transaminase 42 U/L (0–24), glutamic pyruvic transaminase 46 U/L (0–29), γ-glutamyl transferase 381 U/L (8–38). His ESR was also elevated. Ten days after admission, carbamazepine was discontinued. The man’s fever resolved and his liver function had normalised within 3 weeks. The man was rechallenged with carbamazepine 8 weeks later. After 24 hours he experienced a recurrence of fever and hepatic dysfunction so carbamazepine was stopped. His fever resolved and liver function normalised within 7 days. Phenytoin was started to treat his seizures. Author comment: Carbamazepine-induced cholangitis has only been described in 1 other patient. La Spina I, et al. Acute cholangitis induced by carbamazepine. Epilepsia 35: 1029-1031, Sep-Oct 1994 - Italy 800321019 1 Reactions 10 Dec 1994 No. 531 0114-9954/10/0531-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 531 - 10 Dec 1994
Carbamazepine
Cholangitis in an elderly patient: case reportCholangitis in an elderly man was clearly caused by
carbamazepine therapy.Carbamazepine 200mg bid had been started to treat partial
seizures. However, after 4 weeks’ therapy the 66-year-old manwas admitted with a temperature of 39°C and mild upperabdominal pain. His serum liver enzyme levels were asfollows: alkaline phosphatase 628 U/L (normal 73–207),glutamic oxalacetic transaminase 42 U/L (0–24), glutamicpyruvic transaminase 46 U/L (0–29), γ-glutamyl transferase381 U/L (8–38). His ESR was also elevated.
Ten days after admission, carbamazepine was discontinued.The man’s fever resolved and his liver function had normalisedwithin 3 weeks. The man was rechallenged withcarbamazepine 8 weeks later. After 24 hours he experienced arecurrence of fever and hepatic dysfunction so carbamazepinewas stopped. His fever resolved and liver function normalisedwithin 7 days. Phenytoin was started to treat his seizures.
Author comment: Carbamazepine-induced cholangitis hasonly been described in 1 other patient.La Spina I, et al. Acute cholangitis induced by carbamazepine. Epilepsia 35:1029-1031, Sep-Oct 1994 - Italy 800321019
1
Reactions 10 Dec 1994 No. 5310114-9954/10/0531-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
