Carbamazepine
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Reactions 488 - 12 Feb 1994 S Carbamazepine Thrombosis: case report A 57-year-old man was hospitalised twice within 1 month while receiving carbamazepine [dosage not stated] for post- traumatic epilepsy. On both occasions thrombosis was evident. Seven months after he began carbamazepine treatment, the man was admitted to hospital with an MI. Angiography revealed thrombosis of the right coronary artery with no evidence of arteriosclerosis in other coronary branches. His condition improved after symptomatic treatment. One month later he was readmitted with phlebitis of the right lower limb and pulmonary embolism. Thrombosis of the right femoral vein was diagnosed using ultrasonography and embolic images were found in the right lung. Fibrinolysis was begun and favourable progress was made. Laboratory tests showed that blood and platelet counts were normal and no other factors which typically cause thrombosis were present. Carbamazepine was then discontinued, and 15 months later thrombosis had not recurred. Simon JP, et al. Recurrent thrombosis with carbamazepine. Therapie 48: 491, Sep- Oct 1993 [Translated from the original published in French] - France 800241915 1 Reactions 12 Feb 1994 No. 488 0114-9954/10/0488-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 488 - 12 Feb 1994
SCarbamazepine
Thrombosis: case reportA 57-year-old man was hospitalised twice within 1 month
while receiving carbamazepine [dosage not stated] for post-traumatic epilepsy. On both occasions thrombosis wasevident.
Seven months after he began carbamazepine treatment, theman was admitted to hospital with an MI. Angiographyrevealed thrombosis of the right coronary artery with noevidence of arteriosclerosis in other coronary branches. Hiscondition improved after symptomatic treatment.
One month later he was readmitted with phlebitis of theright lower limb and pulmonary embolism. Thrombosis of theright femoral vein was diagnosed using ultrasonography andembolic images were found in the right lung.
Fibrinolysis was begun and favourable progress was made.Laboratory tests showed that blood and platelet counts werenormal and no other factors which typically cause thrombosiswere present. Carbamazepine was then discontinued, and 15months later thrombosis had not recurred.Simon JP, et al. Recurrent thrombosis with carbamazepine. Therapie 48: 491, Sep-Oct 1993 [Translated from the original published in French] - France 800241915
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Reactions 12 Feb 1994 No. 4880114-9954/10/0488-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
