Carbamazepine*
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Carbamazepine • First report of neutrophil Jeukocytosls Although the package insert for carhamazepine(Geigy) lists leuKocytosis as an adverse reaction to carbamazepine. no reports of neutrophilia were found in the literature. A 26-year-old Caucasian woman admitted for psychiatric e1(amination had been taking carbamazepine(600mg/dayl for seizures resulting from a car accident 4 years earlier. A routine hemogram showed a raised WBC coum of21.2 x lOll m l with 82 % neutrophils (normal 60-75 'K,). As it was noted thatleukocylosis was listed as an adverl\e effect of carbamazepine. her medication was changed to phenytoin (400mg I day) and phenobarbital ( I 2001&/ day I. Other drugs were continued unchanged chlorpromazine 125-300mg/day). an<l acetaminophen (paracetamol) with codeine (1·4 tablets/ day). Five days laler the WBC was normal. There were no signs of infection. Recause of dizziness and ataxia. phenytoin and phenobarbital were replaced by carbamazepine (600mgJ day )and WBC I I and I J days later were again significantly raised. \lurphy . JI'.. 01 aL Ameri ",m or \In,plla! Pharma.;y 37, 550fApr Iggf)) 4 Reactions 13Jun 1980 0157-7271 /80/0613·0004 / 0$00.50 /0 ADIS Press
Transcript of Carbamazepine*
Carbamazepine •
First report of neutrophil Jeukocytosls Although the package insert for carhamazepine(Geigy) lists leuKocytosis as an adverse reaction to carbamazepine. no reports of neutrophilia were found in the literature. A 26-year-old Caucasian woman admitted for psychiatric e1(amination had been taking carbamazepine(600mg/dayl for seizures resulting from a car accident 4 years earlier. A routine hemogram showed a raised WBC coum of21.2 x lOll ml with 82 % neutrophils (normal 60-75 'K,). As it was noted thatleukocylosis was listed as an adverl\e effect of carbamazepine. her medication was changed to phenytoin (400mg I day) and phenobarbital ( I 2001&/ day I. Other drugs were continued unchanged ~ chlorpromazine 125-300mg/day). an<l acetaminophen (paracetamol) with codeine (1·4 tablets/ day). Five days laler the WBC was normal. There were no signs of infection . Recause of dizziness and ataxia. phenytoin and phenobarbital were replaced by carbamazepine (600mgJ day )and WBC counL~ I I and I J days later were again significantly raised . \lurphy . JI'.. 01 aL Ameri",m Jnurn~\ or \In,plla! Pharma.;y 37, 550fApr Iggf))
4 Reactions 13Jun 1980 0157-7271 / 80/0613·0004 / 0$00.50 /0 ~ ADIS Press
