Carbamazepine
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Carbamazepine And agranulocytosis A 49-year-old epileptic female with asthma was changed from pbenytoin to carbamazepine 200mg tid. A week later she developed an erythematous non-itchy rash which cleared, but recurred 21/2 weeks later when it was itchy. On day 29 of therapy while cell count was 1.8 x 10 9 /L with a neutrophil count of 0.4 x 10 9 / L. Three days later the patient Was febrile with a wee of 2.7 x 10 9 / L with I % myelocytes and no neutrophils. The generalized maculopapular rash was still present. Five days after withdrawal of carbarnazepine the wee and neutrophil count returned to normal and recovery was uneventful. Theophylline was the only other drug taken during this period and it was continued without interruption. Hawson. G.A.T. eta) : Modical Journal or Australia 1 Ie 82126 Jan 1981)1 4 Reactions 22 Feb 1980 0157-7271/80/0222-0004/0$00.50/0 C AOISPfess
Transcript of Carbamazepine
Carbamazepine
And agranulocytosis A 49-year-old epileptic female with asthma was changed from pbenytoin to carbamazepine 200mg tid. A week later she developed an erythematous non-itchy rash which cleared, but recurred 21/2 weeks later when it was itchy. On day 29 of therapy while cell count was 1.8 x 109/L with a neutrophil count of 0.4 x 109
/ L. Three days later the patient Was febrile with a wee of 2.7 x 109
/ L with I % myelocytes and no neutrophils. The generalized maculopapular rash was still present. Five days after withdrawal of carbarnazepine the wee and neutrophil count returned to normal and recovery was uneventful. Theophylline was the only other drug taken during this period and it was continued without interruption. Hawson. G.A.T. eta) : Modical Journal or Australia 1 Ie 82126 Jan 1981)1
4 Reactions 22 Feb 1980 0157-7271/80/0222-0004/0$00.50/0 C AOISPfess
