Carbamazepine
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Reactions 1393 - 17 Mar 2012 S Carbamazepine Drug hypersensitivity syndrome in an elderly patient: case report An 82-year-old woman developed drug hypersensitivity syndrome following treatment with carbamazepine for trigeminal neuralgia. The woman was hospitalised with pyrexia, exanthema and lymphadenopathy; three weeks prior, carbamazepine was initiated [route, dosage and time to reaction onset not stated]. Examination found disseminated maculopapular eruption in addition to occipital and axillary lymphadenopathy. Tests revealed leucocytosis, eosinophilia, lymphocytosis and thrombocytosis in addition to raised levels of lactate dehydrogenase and β-2 microglobulin; a low mean corpuscular volume was also detected. Splenomegaly and lymphadenopathy were observed on echosonography. She was diagnosed with carbamazepine-induced hypersensitivity syndrome. B cell lymphoma was also identified based on bone marrow biopsy and blood flow cytometry results. Carbamazepine was withdrawn, and corticosteroids were initiated. The woman’s condition subsequently improved. Plavsic A, et al. Carbamazepine-induced hypersensitivity syndrome and low grade B-cell non- Hodgkin lymphoma: A case report. Allergy 66 (Suppl. 94): 375, Jun 2011. Available from: URL: http://dx.doi.org/10.1111/j.1398-9995.2011.02607.x [abstract] - Serbia 803067837 1 Reactions 17 Mar 2012 No. 1393 0114-9954/10/1393-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1393 - 17 Mar 2012
SCarbamazepine
Drug hypersensitivity syndrome in an elderlypatient: case report
An 82-year-old woman developed drug hypersensitivitysyndrome following treatment with carbamazepine fortrigeminal neuralgia.
The woman was hospitalised with pyrexia, exanthemaand lymphadenopathy; three weeks prior, carbamazepinewas initiated [route, dosage and time to reaction onset notstated]. Examination found disseminated maculopapulareruption in addition to occipital and axillarylymphadenopathy. Tests revealed leucocytosis,eosinophilia, lymphocytosis and thrombocytosis inaddition to raised levels of lactate dehydrogenase and β-2microglobulin; a low mean corpuscular volume was alsodetected. Splenomegaly and lymphadenopathy wereobserved on echosonography. She was diagnosed withcarbamazepine-induced hypersensitivity syndrome. B celllymphoma was also identified based on bone marrowbiopsy and blood flow cytometry results.
Carbamazepine was withdrawn, and corticosteroidswere initiated. The woman’s condition subsequentlyimproved.Plavsic A, et al. Carbamazepine-induced hypersensitivity syndrome and low gradeB-cell non- Hodgkin lymphoma: A case report. Allergy 66 (Suppl. 94): 375, Jun2011. Available from: URL: http://dx.doi.org/10.1111/j.1398-9995.2011.02607.x[abstract] - Serbia 803067837
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Reactions 17 Mar 2012 No. 13930114-9954/10/1393-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
