Reactions 1393 - 17 Mar 2012

SCarbamazepine

Drug hypersensitivity syndrome in an elderlypatient: case report

An 82-year-old woman developed drug hypersensitivitysyndrome following treatment with carbamazepine fortrigeminal neuralgia.

The woman was hospitalised with pyrexia, exanthemaand lymphadenopathy; three weeks prior, carbamazepinewas initiated [route, dosage and time to reaction onset notstated]. Examination found disseminated maculopapulareruption in addition to occipital and axillarylymphadenopathy. Tests revealed leucocytosis,eosinophilia, lymphocytosis and thrombocytosis inaddition to raised levels of lactate dehydrogenase and β-2microglobulin; a low mean corpuscular volume was alsodetected. Splenomegaly and lymphadenopathy wereobserved on echosonography. She was diagnosed withcarbamazepine-induced hypersensitivity syndrome. B celllymphoma was also identified based on bone marrowbiopsy and blood flow cytometry results.

Carbamazepine was withdrawn, and corticosteroidswere initiated. The woman’s condition subsequentlyimproved.Plavsic A, et al. Carbamazepine-induced hypersensitivity syndrome and low gradeB-cell non- Hodgkin lymphoma: A case report. Allergy 66 (Suppl. 94): 375, Jun2011. Available from: URL: http://dx.doi.org/10.1111/j.1398-9995.2011.02607.x[abstract] - Serbia 803067837

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Reactions 17 Mar 2012 No. 13930114-9954/10/1393-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved