Carbamazepine
1
Reactions 1420 - 22 Sep 2012 S Carbamazepine DRESS syndrome: 2 case reports Two patients, a man and his mother, developed DRESS syndrome while receiving carbamazepine [dosages and routes not stated]. Elispot assay was positive in both cases, suggesting familial sensitivity to the drug. A 23-year-old man receiving carbamazepine for epilepsy presented with pyrexia, headaches and hepatic dysfunction. He also had a 3-week history of generalised maculopapular exanthema with urticated features, consistent with eosinophilia. He had started carbamazepine 5 weeks before the onset of rash. Histological findings were consistent with DRESS syndrome. Carbamazepine was discontinued and he received a short course of oral steroids and his systemic and cutaneous symptoms resolved a few weeks later. The man’s mother [age not stated] presented 3 months later, with fever, headaches, eosinophilia, abnormal liver function, and a 1-week history of rash. She was also experiencing aphthous ulcers affecting her oral mucosa. She had been receiving carbamazepine for trigeminal neuralgia; she had started the drug 10 weeks before the onset of rash. DRESS syndrome was diagnosed, and carbamazepine was discontinued. She received topical steroids; her rash improved, but systemic and cutaneous symptoms took longer to resolve. Author comment: "We report a familial case of drug reaction with eosinophilia and systemic symptoms (DRESS) to carbamazepine." Anjum N, et al. Familial occurrence of drug reaction with eosinophilia and systemic symptoms to carbamazepine. British Journal of Dermatology 167: 53 abstr. P70, Jul 2012. Available from: URL: http://dx.doi.org/10.1111/ j.1365-2133.2012.10938.x - United Kingdom 803077378 1 Reactions 22 Sep 2012 No. 1420 0114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1420 - 22 Sep 2012
SCarbamazepine
DRESS syndrome: 2 case reportsTwo patients, a man and his mother, developed DRESS
syndrome while receiving carbamazepine [dosages androutes not stated]. Elispot assay was positive in both cases,suggesting familial sensitivity to the drug.
A 23-year-old man receiving carbamazepine for epilepsypresented with pyrexia, headaches and hepaticdysfunction. He also had a 3-week history of generalisedmaculopapular exanthema with urticated features,consistent with eosinophilia. He had startedcarbamazepine 5 weeks before the onset of rash.Histological findings were consistent with DRESSsyndrome. Carbamazepine was discontinued and hereceived a short course of oral steroids and his systemicand cutaneous symptoms resolved a few weeks later.
The man’s mother [age not stated] presented 3 monthslater, with fever, headaches, eosinophilia, abnormal liverfunction, and a 1-week history of rash. She was alsoexperiencing aphthous ulcers affecting her oral mucosa.She had been receiving carbamazepine for trigeminalneuralgia; she had started the drug 10 weeks before theonset of rash. DRESS syndrome was diagnosed, andcarbamazepine was discontinued. She received topicalsteroids; her rash improved, but systemic and cutaneoussymptoms took longer to resolve.
Author comment: "We report a familial case of drugreaction with eosinophilia and systemic symptoms (DRESS) tocarbamazepine."Anjum N, et al. Familial occurrence of drug reaction with eosinophilia andsystemic symptoms to carbamazepine. British Journal of Dermatology 167: 53abstr. P70, Jul 2012. Available from: URL: http://dx.doi.org/10.1111/j.1365-2133.2012.10938.x - United Kingdom 803077378
1
Reactions 22 Sep 2012 No. 14200114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
