Symbole graficzne aparatów, maszyn i urządzeń przemysłu chemicznego
Carbamazepine
1
Reactions 1335 - 22 Jan 2011 S Carbamazepine Toxic epidermal necrolysis: case report A 16-year-old boy presented to an ED with a 3-day history of rapidly progressing skin eruptions. He had started receiving carbamazepine [dosage and route not stated] for his refractory dystonia 1 week earlier. Physical examination revealed erosions on the lips, tongue and buccal mucosa, with coalescing macules becoming progressively vesiculobullous. The lesions covered approximately 70% of his body surface area. Findings from a skin biopsy led to a diagnosis of carbamazepine-induced toxic epidermal necrolysis (TEN). He received IV immune globulin, ophthalmic creams and dressing changes [patient outcome not stated]. Following his discharge from hospital, HLA genotyping showed the presence of the HLA-B*1502 allele. Author comment: "Our case highlights the importance of screening for the HLA-B*1502 allele as a risk factor for . . . TEN drug hypersensitivity in . . . patients who are prescribed carbamazepine. Odueyungbo MA, et al. HLA-B* 1502 allele associated with carbamazepine- induced epidermal necrolysis. Archives of Dermatology 146: 1437-1438, No. 12, Dec 2010. Available from: URL: http://dx.doi.org/10.1001/archdermatol.2010.364 - USA 803048468 1 Reactions 22 Jan 2011 No. 1335 0114-9954/10/1335-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1335 - 22 Jan 2011
SCarbamazepine
Toxic epidermal necrolysis: case reportA 16-year-old boy presented to an ED with a 3-day
history of rapidly progressing skin eruptions. He hadstarted receiving carbamazepine [dosage and route notstated] for his refractory dystonia 1 week earlier. Physicalexamination revealed erosions on the lips, tongue andbuccal mucosa, with coalescing macules becomingprogressively vesiculobullous. The lesions coveredapproximately 70% of his body surface area. Findings froma skin biopsy led to a diagnosis of carbamazepine-inducedtoxic epidermal necrolysis (TEN). He received IV immuneglobulin, ophthalmic creams and dressing changes [patientoutcome not stated]. Following his discharge from hospital,HLA genotyping showed the presence of the HLA-B*1502allele.
Author comment: "Our case highlights the importance ofscreening for the HLA-B*1502 allele as a risk factorfor . . . TEN drug hypersensitivity in . . . patients who areprescribed carbamazepine.Odueyungbo MA, et al. HLA-B* 1502 allele associated with carbamazepine-induced epidermal necrolysis. Archives of Dermatology 146: 1437-1438, No. 12,Dec 2010. Available from: URL: http://dx.doi.org/10.1001/archdermatol.2010.364 -USA 803048468
1
Reactions 22 Jan 2011 No. 13350114-9954/10/1335-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
