Carbamazepine
1
Reactions 1335 - 22 Jan 2011 S Carbamazepine B lymphopenia and agammaglobulinaemia: case report A 29-year-old woman developed B lymphopenia and agammaglobulinaemia during carbamazepine treatment for tonic clonic seizures. The woman was admitted to hospital in August 2003 due to weakness in her extremities. Examination showed weakness of the neck and limbs, exaggerated deep tendon reflexes, positive Babinski sign and sensory loss below C2. Investigations showed enlarged spinal cord lesions. Methylprednisolone improved her symptoms. A month later, she developed multiple episodes of painful tonic spasms on her right arm, which resolved with carbamazepine 400 mg/day [route not stated]. She presented in December with pruritus and skin desquamation, and was later admitted to hospital for pneumonia. Investigations revealed low levels of IgG, IgA and IgM (<84, <5 and <4 mg/dL, respectively), suspected to be caused by carbamazepine [time to reaction onset not clearly stated]. Further tests showed a lymphocyte count of 1/mL 3 and a CD19-positive lymphocyte percentage of 0.11%. B-lymphocyte maturation was disturbed. Carbamazepine was discontinued and the woman received antibacterials and γ-globulin; her symptoms subsequently improved. She was later diagnosed with neuromyelitis optica. Tanaka Y, et al. No relapse of neuromyelitis optica during drug-induced B- Lymphopenia with hypogammaglobulinemia. Neurology 75: e1745-1747, No. 19, 9 Nov 2010. Available from: URL: http://dx.doi.org/10.1212/ wnl.0b013e3181fc2788 - Japan 803048197 1 Reactions 22 Jan 2011 No. 1335 0114-9954/10/1335-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1335 - 22 Jan 2011
SCarbamazepine
B lymphopenia and agammaglobulinaemia: casereport
A 29-year-old woman developed B lymphopenia andagammaglobulinaemia during carbamazepine treatmentfor tonic clonic seizures.
The woman was admitted to hospital in August 2003 dueto weakness in her extremities. Examination showedweakness of the neck and limbs, exaggerated deep tendonreflexes, positive Babinski sign and sensory loss below C2.Investigations showed enlarged spinal cord lesions.Methylprednisolone improved her symptoms. A monthlater, she developed multiple episodes of painful tonicspasms on her right arm, which resolved withcarbamazepine 400 mg/day [route not stated]. Shepresented in December with pruritus and skindesquamation, and was later admitted to hospital forpneumonia. Investigations revealed low levels of IgG, IgAand IgM (<84, <5 and <4 mg/dL, respectively), suspectedto be caused by carbamazepine [time to reaction onset notclearly stated]. Further tests showed a lymphocyte count of1/mL3 and a CD19-positive lymphocyte percentage of0.11%. B-lymphocyte maturation was disturbed.
Carbamazepine was discontinued and the womanreceived antibacterials and γ-globulin; her symptomssubsequently improved. She was later diagnosed withneuromyelitis optica.Tanaka Y, et al. No relapse of neuromyelitis optica during drug-induced B-Lymphopenia with hypogammaglobulinemia. Neurology 75: e1745-1747, No. 19,9 Nov 2010. Available from: URL: http://dx.doi.org/10.1212/wnl.0b013e3181fc2788 - Japan 803048197
1
Reactions 22 Jan 2011 No. 13350114-9954/10/1335-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
