Carbamazepine
Transcript of Carbamazepine
Reactions 1404 - 2 Jun 2012
SCarbamazepine
Toxic encephalopathy in an elderly patient: casereport
A 70-year-old woman developed toxic encephalopathy[route not stated] during treatment with carbamazepine forepilepsy.
The woman initially received carbamazepine 200mgwhich resulted in complete and rapid seizure control. Herdose was increased and, 3 days later, she was receivingcarbamazepine 300 mg/day. At that time, she developedencephalopathy with hypersomnia, confusion,psychomotor slowness, and memory impairment. EEGrecordings revealed a generalised, mild, slowing withbursts of frontal intermittent rhythmic delta activity(FIRDA). Her carbamazepine concentration was22.6 µg/mL.
Carbamazepine was discontinued and the womanreceived valproic acid instead. She improved dramaticallywithin a few days. The EEG findings of FIRDA and diffuseslowing disappeared and there was a full recovery ofphysiological activities. At her 8-month follow-up, an EEGshowed no FIRDA and there were no adverse events withvalproic acid.
Author comment: "In our patient, there was a cleartemporal relationship between drug administration, drugserum levels (above normal range), and the development ofthe encephalopathy."Milia A, et al. Reversible carbamazapine encephalopathy with frontal intermittentrhythmic delta activity. Journal of Neuropsychiatry and Clinical Neurosciences 23:21-22, No. 4, 2011 - Italy 803071212
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Reactions 2 Jun 2012 No. 14040114-9954/10/1404-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved