Carbamazepine
1
Reactions 1374 - 22 Oct 2011 S Carbamazepine Fetal carbamazepine syndrome after in utero exposure: case report A female neonate was born with fetal carbamazepine syndrome after in utero exposure to carbamazepine, and later died. The girl was born by Caesarean section after 36.6 weeks’ gestation to a 33-year-old mother with epilepsy. The mother had taken oral carbamazepine 400 mg/day throughout the pregnancy. The girl showed abnormalities including generalised hypotrophy, a long head and narrow forehead, abnormal facial features, kyphosis, hypoplastic nails and a lumbosacral myelomeningocele. Neurological examination revealed hyporeactivity, lack of rooting and suckling reflexes, absent deep tendon reflexes in her legs, and absent anal tone. She developed respiratory distress soon after birth, and was intubated. An echocardiogram revealed pulmonary hypertension. Infection was suspected, and the girl was started on antibacterials. A blood count revealed neutropenia. On day 7 of life, she developed refractory respiratory alkalosis and died. Author comment: "We describe a newborn with several congenital malformations that died within the first week of life due to the severity of the abnormalities probably caused by in utero exposure to this drug." Bravo A, et al. Severe consequences of carbamazepine exposure in utero. BMJ Case Reports : [3 pages], 2011. Available from: URL: http://dx.doi.org/10.1136/ bcr.05.2011.4243 - Mexico 803061635 1 Reactions 22 Oct 2011 No. 1374 0114-9954/10/1374-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1374 - 22 Oct 2011
SCarbamazepine
Fetal carbamazepine syndrome after in uteroexposure: case report
A female neonate was born with fetal carbamazepinesyndrome after in utero exposure to carbamazepine, andlater died.
The girl was born by Caesarean section after 36.6 weeks’gestation to a 33-year-old mother with epilepsy. Themother had taken oral carbamazepine 400 mg/daythroughout the pregnancy. The girl showed abnormalitiesincluding generalised hypotrophy, a long head and narrowforehead, abnormal facial features, kyphosis, hypoplasticnails and a lumbosacral myelomeningocele. Neurologicalexamination revealed hyporeactivity, lack of rooting andsuckling reflexes, absent deep tendon reflexes in her legs,and absent anal tone.
She developed respiratory distress soon after birth, andwas intubated. An echocardiogram revealed pulmonaryhypertension. Infection was suspected, and the girl wasstarted on antibacterials. A blood count revealedneutropenia. On day 7 of life, she developed refractoryrespiratory alkalosis and died.
Author comment: "We describe a newborn with severalcongenital malformations that died within the first week oflife due to the severity of the abnormalities probably causedby in utero exposure to this drug."Bravo A, et al. Severe consequences of carbamazepine exposure in utero. BMJCase Reports : [3 pages], 2011. Available from: URL: http://dx.doi.org/10.1136/bcr.05.2011.4243 - Mexico 803061635
1
Reactions 22 Oct 2011 No. 13740114-9954/10/1374-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
