Carbamazepine
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Reactions 1285 - 23 Jan 2010 S Carbamazepine DRESS syndrome: case report A 38-year-old woman with a history of bipolar disorder developed drug rash with eosinophilia and systemic symptoms (DRESS) syndrome during treatment with carbamazepine. The woman, who had been receiving carbamazepine for 6 weeks [dosage and therapeutic indication not stated], was hospitalised with a 4-day history of a skin rash, and a fever. On admission, she had a maculopapular rash on her arms, and erythroderma on her legs, back, abdomen and chest. Her body temperature was 101.6°F, her AST level was 85, her ALT level was 73, her CRP level was 8.1 mg/dL, and she had serum eosinophilia. Carbamazepine was withdrawn on hospital day 1, and methylprednisolone was started. The woman’s eosinophilia resolved after 5 days of treatment. An attempt was made to taper corticosteroids, but her rash became more painful. After 17 days of methylprednisolone, she was switched to prednisone. One month after admission, her transaminase levels normalised. After 8 weeks of treatment, her rash completely resolved. She developed a pruritic rash 16 weeks after her initial presentation; prednisone was increased for 1 week, then gradually tapered; her symptoms improved. Shah R, et al. LONG DURATION OF DRESS FROM CARBAMAZEPINE. 2009 Annual Meeting of the American College of Allergy, Asthma and Immunology : abstr. P16, 5 Nov 2009. Available from: URL: http://www.acaai.org - USA 803004572 1 Reactions 23 Jan 2010 No. 1285 0114-9954/10/1285-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Carbamazepine
Reactions 1285 - 23 Jan 2010
SCarbamazepine
DRESS syndrome: case reportA 38-year-old woman with a history of bipolar disorder
developed drug rash with eosinophilia and systemicsymptoms (DRESS) syndrome during treatment withcarbamazepine.
The woman, who had been receiving carbamazepine for6 weeks [dosage and therapeutic indication not stated], washospitalised with a 4-day history of a skin rash, and a fever.On admission, she had a maculopapular rash on her arms,and erythroderma on her legs, back, abdomen and chest.Her body temperature was 101.6°F, her AST level was 85,her ALT level was 73, her CRP level was 8.1 mg/dL, and shehad serum eosinophilia.
Carbamazepine was withdrawn on hospital day 1, andmethylprednisolone was started. The woman’seosinophilia resolved after 5 days of treatment. An attemptwas made to taper corticosteroids, but her rash becamemore painful. After 17 days of methylprednisolone, she wasswitched to prednisone. One month after admission, hertransaminase levels normalised. After 8 weeks oftreatment, her rash completely resolved. She developed apruritic rash 16 weeks after her initial presentation;prednisone was increased for 1 week, then graduallytapered; her symptoms improved.Shah R, et al. LONG DURATION OF DRESS FROM CARBAMAZEPINE. 2009Annual Meeting of the American College of Allergy, Asthma and Immunology :abstr. P16, 5 Nov 2009. Available from: URL: http://www.acaai.org -USA 803004572
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Reactions 23 Jan 2010 No. 12850114-9954/10/1285-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
