Carbamazepine
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Reactions 1183 - 5 Jan 2008 S Carbamazepine DRESS syndrome in a child: case report A 10-year-old girl developed drug rash with eosinophilia and systemic symptoms (DRESS) syndrome during treatment with carbamazepine for complex partial seizures. The girl started receiving carbamazepine and, over 4 weeks, her dosage was gradually increased to 2 x 600mg [initial dosage and frequency of administration not stated]. Subsequently, she was noted to become progressively somnolent; she developed fever of up to 39.5°C and presented to a hospital the following day [duration of treatment to reaction onset not stated]. On presentation, her general condition was reduced, she had a maculopapular exanthema, and her cervical and inguinal lymph nodes were enlarged. Laboratory investigations revealed the following levels: AST 538 U/L, ALT 789 U/L, γ-glutamyl transferase 655 U/L, glutamate dehydrogenase 156/L, ALP 359 U/L, lactate dehydrogenase 1211 U/L, total bilirubin 0.6 mg/dL, ammonia 53 µmol/L, amylase 23 U/L and lipase 15 U/L. She had a WBC count of 5.5 G/L with 19% eosinophils, and her carbamazepine concentration was 47 µmol/L; human herpes virus-6 IgG was positive and IgM was borderline. An abdominal ultrasound showed a slightly enlarged liver and markedly enlarged spleen (174mL volume). The girl was admitted and carbamazepine was discontinued. Her clinical condition progressively improved and her liver values slowly normalised. Her treatment was changed to levetiracetam 3 weeks after carbamazepine discontinuation. Wurpts G, et al. DRESS syndrome caused by carbamazepine. Hautarzt 58: 935-936, No. 11, Nov 2007 [German] - Germany 801096081 1 Reactions 5 Jan 2008 No. 1183 0114-9954/10/1183-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1183 - 5 Jan 2008
SCarbamazepine
DRESS syndrome in a child: case reportA 10-year-old girl developed drug rash with eosinophilia and
systemic symptoms (DRESS) syndrome during treatment withcarbamazepine for complex partial seizures.
The girl started receiving carbamazepine and, over 4 weeks,her dosage was gradually increased to 2 x 600mg [initialdosage and frequency of administration not stated].Subsequently, she was noted to become progressivelysomnolent; she developed fever of up to 39.5°C and presentedto a hospital the following day [duration of treatment toreaction onset not stated]. On presentation, her generalcondition was reduced, she had a maculopapular exanthema,and her cervical and inguinal lymph nodes were enlarged.Laboratory investigations revealed the following levels: AST538 U/L, ALT 789 U/L, γ-glutamyl transferase 655 U/L,glutamate dehydrogenase 156/L, ALP 359 U/L, lactatedehydrogenase 1211 U/L, total bilirubin 0.6 mg/dL, ammonia53 µmol/L, amylase 23 U/L and lipase 15 U/L. She had a WBCcount of 5.5 G/L with 19% eosinophils, and her carbamazepineconcentration was 47 µmol/L; human herpes virus-6 IgG waspositive and IgM was borderline. An abdominal ultrasoundshowed a slightly enlarged liver and markedly enlarged spleen(174mL volume).
The girl was admitted and carbamazepine was discontinued.Her clinical condition progressively improved and her livervalues slowly normalised. Her treatment was changed tolevetiracetam 3 weeks after carbamazepine discontinuation.Wurpts G, et al. DRESS syndrome caused by carbamazepine. Hautarzt 58:935-936, No. 11, Nov 2007 [German] - Germany 801096081
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Reactions 5 Jan 2008 No. 11830114-9954/10/1183-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
