Carbamazepine
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Reactions 682 - 20 Dec 1997 Carbamazepine Lupus-like syndrome: case report A 40-year-old woman developed a lupus-like syndrome while receiving carbamazepine 400 mg/day for a right epileptic focus. One year after she began carbamazepine therapy, the woman presented with red macules on her face and Raynaud’s phenomenon of her extremities. She had pink and violaceous cutaneous papules over her phalangeal and carpal joints and the eruption had a lichenoid appearance on her arm and hand. Her antinuclear antibody (ANA) titre was positive at 1/320. Thirteen months later, the woman presented again with redness, pain and burning on her face and arms in a photosensitivity-like distribution. Her ANA titre was 1/1280 and her anti-dsDNA and antihistone antibodies had become positive. Six months later, a skin biopsy was consistent with a lichen- planus-like eruption. The woman’s ANA titre remained at 1/1280 and her anti-dsDNA and antihistone antibodies were still positive. Carbamazepine was replaced with valproic acid. Six months later, the cutaneous lichenoid eruption had progressively improved and the anti-DNA and antihistone antibodies were negative, but the ANA titre was unchanged. Author comment: ‘Based on the clinical improvement after carbamazepine withdrawal, the auto-antibody profile and its evolution, we assume that this patient had a carbamazepine- induced lupus-like syndrome.’ Reiffers-Mettelock J, et al. Syndrome resembling systemic lupus erythematosus induced by carbamazepine. Dermatology 195: 306-307, No. 3, 1997 - Luxembourg 800616391 1 Reactions 20 Dec 1997 No. 682 0114-9954/10/0682-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 682 - 20 Dec 1997
Carbamazepine
Lupus-like syndrome: case reportA 40-year-old woman developed a lupus-like syndrome
while receiving carbamazepine 400 mg/day for a right epilepticfocus.
One year after she began carbamazepine therapy, thewoman presented with red macules on her face and Raynaud’sphenomenon of her extremities. She had pink and violaceouscutaneous papules over her phalangeal and carpal joints andthe eruption had a lichenoid appearance on her arm and hand.Her antinuclear antibody (ANA) titre was positive at 1/320.
Thirteen months later, the woman presented again withredness, pain and burning on her face and arms in aphotosensitivity-like distribution. Her ANA titre was 1/1280and her anti-dsDNA and antihistone antibodies had becomepositive.
Six months later, a skin biopsy was consistent with a lichen-planus-like eruption. The woman’s ANA titre remained at1/1280 and her anti-dsDNA and antihistone antibodies werestill positive. Carbamazepine was replaced with valproic acid.Six months later, the cutaneous lichenoid eruption hadprogressively improved and the anti-DNA and antihistoneantibodies were negative, but the ANA titre was unchanged.
Author comment: ‘Based on the clinical improvement aftercarbamazepine withdrawal, the auto-antibody profile and itsevolution, we assume that this patient had a carbamazepine-induced lupus-like syndrome.’Reiffers-Mettelock J, et al. Syndrome resembling systemic lupus erythematosusinduced by carbamazepine. Dermatology 195: 306-307, No. 3, 1997 -Luxembourg 800616391
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Reactions 20 Dec 1997 No. 6820114-9954/10/0682-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
