Carbamazepine
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Reactions 910 - 13 Jul 2002 Carbamazepine Various toxicities: case report A man in his forties developed a high fever associated with blood dyscrasias and liver function abnormalities during carbamazepine treatment for a mood disorder. The man had been receiving carbamazepine 200 mg/day for 13 days when his dosage was increased to 400 mg/day. He presented 5 days later with a 2-week history of intermittent fever, headaches and severe constitutional symptoms. Examination revealed a temperature of 39.8°C and a few petechiae on his trunk. Laboratory investigations revealed leucopenia (2.3 × 10 9 /L), neutropenia (0.4 × 10 9 /L), lymphopenia (0.5 × 10 9 /L) and thrombocytopenia (28 × 10 9 /L). Investigations also showed γ-glutamyl transferase, ALT, AST and alkaline phosphatase levels of 789, 285, 121 and 334 IU/L, respectively, and a bilirubin level of 24 µmol/L. Carbamazepine was discontinued and the man’s fever settled after 4 days. His haematological and liver function abnormalities resolved completely in the weeks following carbamazepine discontinuation. Anpalahan M. Carbamazepine toxicity. Australian Prescriber 25: 73-74, No. 3, 2002 - Australia 800911987 1 Reactions 13 Jul 2002 No. 910 0114-9954/10/0910-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 910 - 13 Jul 2002
Carbamazepine
Various toxicities: case reportA man in his forties developed a high fever associated with
blood dyscrasias and liver function abnormalities duringcarbamazepine treatment for a mood disorder.
The man had been receiving carbamazepine 200 mg/day for13 days when his dosage was increased to 400 mg/day. Hepresented 5 days later with a 2-week history of intermittentfever, headaches and severe constitutional symptoms.Examination revealed a temperature of 39.8°C and a fewpetechiae on his trunk. Laboratory investigations revealedleucopenia (2.3 × 109/L), neutropenia (0.4 × 109/L),lymphopenia (0.5 × 109/L) and thrombocytopenia (28 × 109/L).Investigations also showed γ-glutamyl transferase, ALT, ASTand alkaline phosphatase levels of 789, 285, 121 and 334 IU/L,respectively, and a bilirubin level of 24 µmol/L.
Carbamazepine was discontinued and the man’s feversettled after 4 days. His haematological and liver functionabnormalities resolved completely in the weeks followingcarbamazepine discontinuation.Anpalahan M. Carbamazepine toxicity. Australian Prescriber 25: 73-74, No. 3,2002 - Australia 800911987
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Reactions 13 Jul 2002 No. 9100114-9954/10/0910-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
