Carbamazepine
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Reactions 1453 - 25 May 2013 S Carbamazepine DRESS: 2 case reports A 23-year-old man and his mother [age not stated] developed DRESS while receiving carbamazepine [routes, dosages and durations of treatment to reaction onset not stated]. The man received carbamazepine for epilepsy, and presented with DRESS. Three months later, his mother received carbamazepine for trigeminal neuralgia, and presented with a similar rash. Histological, haematological and biochemical features were consistent with DRESS. Carbamazepine was withdrawn, and both patients received steroid treatment. Their cutaneous features and systemic upset resolved. Carbamazepine-specific lymphocyte proliferation and interleukin-4 assays results confirmed the clinical suspicion of DRESS. Both patients were positive for the HLA-A*3101 allele, shown to be associated with carbamazepine-induced hypersensitivity. Author comment: "The association of anticonvulsant agents, including carbamazepine, with DRESS among other cutaneous reactions is well known . . . Our cases demonstrate the importance of considering family history of cutaneous reactions when prescribing carbamazepine". Anjum N. The importance of family history when prescribing anticonvulsants. British Journal of Dermatology 168: e3, No. 4, Apr 2013. Available from: URL: http://dx.doi.org/10.1111/j.1365-2133.2013.12274.x - United Kingdom 803087269 » Editorial comment: Details of this case report have previously been published [see Reactions 1420 p17; 803077378]. 1 Reactions 25 May 2013 No. 1453 0114-9954/10/1453-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1453 - 25 May 2013
SCarbamazepine
DRESS: 2 case reportsA 23-year-old man and his mother [age not stated]
developed DRESS while receiving carbamazepine [routes,dosages and durations of treatment to reaction onset notstated].
The man received carbamazepine for epilepsy, andpresented with DRESS. Three months later, his motherreceived carbamazepine for trigeminal neuralgia, andpresented with a similar rash. Histological, haematological andbiochemical features were consistent with DRESS.
Carbamazepine was withdrawn, and both patients receivedsteroid treatment. Their cutaneous features and systemicupset resolved. Carbamazepine-specific lymphocyteproliferation and interleukin-4 assays results confirmed theclinical suspicion of DRESS. Both patients were positive for theHLA-A*3101 allele, shown to be associated withcarbamazepine-induced hypersensitivity.
Author comment: "The association of anticonvulsantagents, including carbamazepine, with DRESS among othercutaneous reactions is well known . . . Our casesdemonstrate the importance of considering family history ofcutaneous reactions when prescribing carbamazepine".Anjum N. The importance of family history when prescribing anticonvulsants.British Journal of Dermatology 168: e3, No. 4, Apr 2013. Available from: URL:http://dx.doi.org/10.1111/j.1365-2133.2013.12274.x - United Kingdom 803087269
» Editorial comment: Details of this case report havepreviously been published [see Reactions 1420 p17;803077378].
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Reactions 25 May 2013 No. 14530114-9954/10/1453-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
