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I. Anemias of Blood Loss

Acute trauma

Chronic

lesions of GI tract, gynecologic

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II. Hemolytic Anemias

Intrinsic / Intracorpuscular

Hereditary Membrane disorders - HS

Enzyme deficiencies - G-6PD

Disorders of Hb synthesis

Deficient Hb synthesis - thalassemia

Structurally abnormal globin synthesis sickle cells

Acquired

Membrane defect - PNH

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II. Hemolytic Anemias

Extrinsic / Extracorpuscular

Antibody mediated Isohemagglutinis (HTR, EF), Autoabs (SLE,

Mycoplasma), AIHA (warm, cold, PCH)

Mechanical trauma to RBC - DIC

Infections - malaria Chemical injury Pb poisoning

Sequestration in mononuclear phagocytesystem (hypersplenism)

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III. Anemias of Diminished

Erythropoiesis/Impaired RC Production

Disturbance of proliferation &differentiation of stem cells

Aplastic Anemia

Acquired, idiopathic, Fanconi (familial)

Pure red cell aplasia

Congenital erythroid hypoplasia -Diamond Blackfan

Acquired acute / chronic

Anemia of renal failure

Anemia of endocrine disorder

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III. Anemias of Diminished

Erythropoiesis/Impaired RC Production

Disturbance of proliferation & maturationof stem cells

Defective DNA synthesis

Megaloblastic anemia B12(pernicious), folate

Defective Hb synthesis

Deficient heme synthesis

Fe deficiency

Deficient globin synthesis - thalassemias

Unknown or multiple mechanisms

Sideroblastic, anemia of chronic infections

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WBC Disorders

Leukopenia

Reactive (inflammatory) proliferations ofWBC & nodes

Leukocytosis

Non specific lymphadenitis (acute, chronic) Neoplastic proliferation

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Neoplastic proliferation

Lymphoid

Precursor B and T cell neoplasms

ALL

Precursor B cell neoplasms

CLL, Burkitt, plasma cell neoplasms, multiplemyleoma, hairy cell leukemia

Peripheral T cell and NK neoplasms

Mycosis fungoides

Hodgkin Disease

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Neoplastic proliferation

Myeloid

AML Myelodysplastic syndromes

Chronic myeloproliferative disorders

CML

Polycythemia vera

Essential thrombocytosis

Myelofibrosis with myeloid metaplasia

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