Benazepril
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Reactions 739 - 20 Feb 1999 ★ S Benazepril First report of pancreatitis in an elderly patient: case report A 70-year-old man with type 2 diabetes mellitus developed pancreatitis following treatment with benazepril for essential hypertension. Thirty minutes after taking his first dose of benazepril, the man experienced severe epigastric pain and cramping that continued for 6–8 hours. The next day, he experienced the same symptoms after taking his second dose, and the agent was discontinued. The man then experienced 2 episodes of vomiting and was not able to eat for 4 days. Approximately 1 week after the start of benazepril therapy, he decided to take a third dose of the agent (5mg) because of a high home BP reading. Once again, he experienced epigastric pain, nausea and vomiting. The patient presented to an emergency department. Tests showed sinus tachycardia and moderate epigastric tenderness. His serum amylase and lipase levels were 234 and 755 U/L, respectively. An abdominal CT scan showed a mildly oedematous, inflamed pancreas and a single, non-obstructing gall stone. The man was treated with bowel rest and pethidine [meperidine]. His pain improved over the following week and he started to tolerate food. At the time of discharge, his serum amylase and lipase levels were 50 and 189 U/L, respectively. Author comment: ‘Our patient clearly developed pancreatitis that was related to benazepril ingestion on three separate occasions.’ Muchnick JS, et al. Angiotensin-converting enzyme inhibitor-induced pancreatitis. Clinical Cardiology 22: 50-51, Jan 1999 - USA 800740052 » Editorial comment: A search of AdisBase and Medline did not reveal any case previous reports of pancreatitis associated with benazepril. 1 Reactions 20 Feb 1999 No. 739 0114-9954/10/0739-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Benazepril
Reactions 739 - 20 Feb 1999
★ SBenazepril
First report of pancreatitis in an elderly patient:case report
A 70-year-old man with type 2 diabetes mellitus developedpancreatitis following treatment with benazepril for essentialhypertension.
Thirty minutes after taking his first dose of benazepril, theman experienced severe epigastric pain and cramping thatcontinued for 6–8 hours. The next day, he experienced thesame symptoms after taking his second dose, and the agentwas discontinued.
The man then experienced 2 episodes of vomiting and wasnot able to eat for 4 days. Approximately 1 week after the startof benazepril therapy, he decided to take a third dose of theagent (5mg) because of a high home BP reading. Once again,he experienced epigastric pain, nausea and vomiting.
The patient presented to an emergency department. Testsshowed sinus tachycardia and moderate epigastric tenderness.His serum amylase and lipase levels were 234 and 755 U/L,respectively. An abdominal CT scan showed a mildlyoedematous, inflamed pancreas and a single, non-obstructinggall stone.
The man was treated with bowel rest and pethidine[meperidine]. His pain improved over the following week andhe started to tolerate food. At the time of discharge, his serumamylase and lipase levels were 50 and 189 U/L, respectively.
Author comment: ‘Our patient clearly developedpancreatitis that was related to benazepril ingestion on threeseparate occasions.’Muchnick JS, et al. Angiotensin-converting enzyme inhibitor-induced pancreatitis.Clinical Cardiology 22: 50-51, Jan 1999 - USA 800740052
» Editorial comment: A search of AdisBase and Medline didnot reveal any case previous reports of pancreatitis associatedwith benazepril.
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Reactions 20 Feb 1999 No. 7390114-9954/10/0739-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
