Antineoplastics/corticosteroids
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Reactions 1246 - 4 Apr 2009 S Antineoplastics/corticosteroids Multifocal osteonecrosis in a child: case report A 12-year-old girl developed multifocal osteonecrosis during treatment with antineoplastics and high dose corticosteroids. The girl was diagnosed with acute lymphoblastic leukaemia (ALL) and underwent treatment according to the national protocol AIEOP 9502 non–T [drugs and dosages not clearly defined], including administration of antineoplastics and high-dose corticosteroids. About 6 months after commencing treatment, she reported mild pain in her left knee; a diffuse swelling of the joint was later noticed. No appreciable suspicious lesions were observed on x-ray; however, MRI showed a focal zone of avascular bone necrosis on the lateral femoral condyle. Seven months later, she reported pain and progressive stiffness in her left hip. Limited internal and external rotation and abduction of the left hip were observed during examination. X-ray revealed an initial left femoral head irregularity and narrowing of the joint. After a further 9 months, 22 months after commencing treatment, symptoms were present in her right hip and both shoulders. Functional limitations were observed and x-rays revealed the presence of osteonecrotic processes in the three sites. The girl underwent bilateral total hip arthroplasty. The diagnosis was confirmed upon histological examination. At last follow-up, performed after 5 years and 4 months, the arthroplasty was still functioning well [patient outcome not clearly stated]. Solarino G, et al. On a case of multifocal osteonecrosis in a patient suffering from acute lymphoblastic leukemia. Chirurgia degli Organi di Movimento 92: 119-122, No. 2, Sep 2008 - Italy 801138441 » Editorial comment: The authors cited the following reference for the protocol: Aric` o M, Boccalatte MF, Silvestri D et al. Haematologica 2003; 88 : 747–753 1 Reactions 4 Apr 2009 No. 1246 0114-9954/10/1246-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics/corticosteroids
Reactions 1246 - 4 Apr 2009
SAntineoplastics/corticosteroids
Multifocal osteonecrosis in a child: case reportA 12-year-old girl developed multifocal osteonecrosis
during treatment with antineoplastics and high dosecorticosteroids.
The girl was diagnosed with acute lymphoblasticleukaemia (ALL) and underwent treatment according to thenational protocol AIEOP 9502 non–T [drugs and dosagesnot clearly defined], including administration ofantineoplastics and high-dose corticosteroids. About6 months after commencing treatment, she reported mildpain in her left knee; a diffuse swelling of the joint was laternoticed. No appreciable suspicious lesions were observedon x-ray; however, MRI showed a focal zone of avascularbone necrosis on the lateral femoral condyle. Sevenmonths later, she reported pain and progressive stiffness inher left hip. Limited internal and external rotation andabduction of the left hip were observed duringexamination. X-ray revealed an initial left femoral headirregularity and narrowing of the joint. After a further9 months, 22 months after commencing treatment,symptoms were present in her right hip and bothshoulders. Functional limitations were observed and x-raysrevealed the presence of osteonecrotic processes in thethree sites.
The girl underwent bilateral total hip arthroplasty. Thediagnosis was confirmed upon histological examination. Atlast follow-up, performed after 5 years and 4 months, thearthroplasty was still functioning well [patient outcome notclearly stated].Solarino G, et al. On a case of multifocal osteonecrosis in a patient suffering fromacute lymphoblastic leukemia. Chirurgia degli Organi di Movimento 92: 119-122,No. 2, Sep 2008 - Italy 801138441
» Editorial comment: The authors cited the followingreference for the protocol: Arico M, Boccalatte MF, SilvestriD et al. Haematologica 2003; 88 : 747–753
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Reactions 4 Apr 2009 No. 12460114-9954/10/1246-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
