Antineoplastics
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Reactions 522 - 8 Oct 1994 Antineoplastics Candidiasis: 12 case reports A syndrome with clinical and radiological features of hepatic, splenic or renal candidiasis occurred in 12 women (aged 34–57 years) who had received high-dose antineoplastic therapy and autologous bone marrow transplantation for metastatic breast cancer. However, in contrast to classic cases of hepatosplenic candidiasis, most of these patients were asymptomatic and had a better overall outcome. Nine of the patients had received cyclophosphamide 1875 mg/m 2 /day and cisplatin 55 mg/m 2 /day for 3 days, and carmustine 600 mg/m 2 once after the cisplatin infusion was completed. Two patients received a similar regimen with thiotepa 600 mg/m 2 instead of carmustine. The other patient received ifosfamide 2.66 g/m 2 /day and carboplatin 200 mg/m 2 /day for 3 days, and melphalan 80 mg/m 2 once. CT scans showed lesions consistent with candidiasis of the liver and spleen (2 patients) liver (2), kidneys (2), spleen (2) or spleen and kidneys (3). However, only 5 patients had symptoms at the time of these CT scans; 4 had fever and 1 had dysuria. Most patients had abnormal liver function tests at the time of CT scans. Candida was isolated from blood or tissue cultures in 5 patients. Some patients improved either with or without antifungal therapy, and others had no change in their radiographic abnormalities despite antifungal therapy. Six patients subsequently died; however, none of the deaths were directly related to the presumed systemic candidiasis. Mudad R, et al. A radiologic syndrome after high dose chemotherapy and autologous bone marrow transplantation, with clinical and pathologic features of systemic candidiasis. Cancer 74: 1360-1366, 15 Aug 1994 - USA 800301047 1 Reactions 8 Oct 1994 No. 522 0114-9954/10/0522-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 522 - 8 Oct 1994
Antineoplastics
Candidiasis: 12 case reportsA syndrome with clinical and radiological features of
hepatic, splenic or renal candidiasis occurred in 12 women(aged 34–57 years) who had received high-dose antineoplastictherapy and autologous bone marrow transplantation formetastatic breast cancer. However, in contrast to classic casesof hepatosplenic candidiasis, most of these patients wereasymptomatic and had a better overall outcome.
Nine of the patients had received cyclophosphamide 1875mg/m2/day and cisplatin 55 mg/m2/day for 3 days, andcarmustine 600 mg/m2 once after the cisplatin infusion wascompleted. Two patients received a similar regimen withthiotepa 600 mg/m2 instead of carmustine. The other patientreceived ifosfamide 2.66 g/m2/day and carboplatin 200mg/m2/day for 3 days, and melphalan 80 mg/m2 once.
CT scans showed lesions consistent with candidiasis of theliver and spleen (2 patients) liver (2), kidneys (2), spleen (2) orspleen and kidneys (3). However, only 5 patients hadsymptoms at the time of these CT scans; 4 had fever and 1 haddysuria. Most patients had abnormal liver function tests at thetime of CT scans. Candida was isolated from blood or tissuecultures in 5 patients.
Some patients improved either with or without antifungaltherapy, and others had no change in their radiographicabnormalities despite antifungal therapy. Six patientssubsequently died; however, none of the deaths were directlyrelated to the presumed systemic candidiasis.Mudad R, et al. A radiologic syndrome after high dose chemotherapy andautologous bone marrow transplantation, with clinical and pathologic features ofsystemic candidiasis. Cancer 74: 1360-1366, 15 Aug 1994 - USA 800301047
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Reactions 8 Oct 1994 No. 5220114-9954/10/0522-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
