Antineoplastics
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Reactions 584 - 20 Jan 1996 S Antineoplastics Myocardial infarction: case report A close temporal association between the administration of adjuvant antineoplastic therapy for testicular cancer and myocardial infarction in a 36-year-old man suggested a cause and effect relationship. The man’s antineoplastic regimen consisted of bleomycin 30mg on days 2, 9 and 16, etoposide 100 mg/m 2 on day 1–5 and cisplatin 20 mg/m 2 on days 1–5. Nine days after he began the antineoplastic regimen, the man experienced an anteroseptal myocardial infarction and was treated with alteplase. Five days later, the man developed severe thrombocytopenia and required a platelet transfusion. The man subsequently recovered. He did not receive any further adjuvant antineoplastic therapy and his cancer remained in remission at follow-up 11 months later. Author comment: There have been 23 previous cases of acute myocardial infarction in patients treated with cisplatin- based antineoplastic therapy reported in the literature. Gerl A, et al. Myocardial infarction after adjuvant chemotherapy for resected stage II nonseminomatous testicular cancer. Oncology Reports 2: 1097-1099, Nov-Dec 1995 - Germany 807094007 1 Reactions 20 Jan 1996 No. 584 0114-9954/10/0584-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 584 - 20 Jan 1996
SAntineoplastics
Myocardial infarction: case reportA close temporal association between the administration of
adjuvant antineoplastic therapy for testicular cancer andmyocardial infarction in a 36-year-old man suggested a causeand effect relationship.
The man’s antineoplastic regimen consisted of bleomycin30mg on days 2, 9 and 16, etoposide 100 mg/m2 on day 1–5and cisplatin 20 mg/m2 on days 1–5. Nine days after he beganthe antineoplastic regimen, the man experienced ananteroseptal myocardial infarction and was treated withalteplase.
Five days later, the man developed severethrombocytopenia and required a platelet transfusion. Theman subsequently recovered. He did not receive any furtheradjuvant antineoplastic therapy and his cancer remained inremission at follow-up 11 months later.
Author comment: There have been 23 previous cases ofacute myocardial infarction in patients treated with cisplatin-based antineoplastic therapy reported in the literature.Gerl A, et al. Myocardial infarction after adjuvant chemotherapy for resected stageII nonseminomatous testicular cancer. Oncology Reports 2: 1097-1099, Nov-Dec1995 - Germany 807094007
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Reactions 20 Jan 1996 No. 5840114-9954/10/0584-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
