Antineoplastics
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Reactions 504 - 4 Jun 1994 Antineoplastics Nose disorders: incidence study Nasal mucociliary clearance was found to be transiently impaired in 92% of patients receiving antineoplastic regimens prior to undergoing bone marrow transplantation, according to the results of a US study. Antineoplastic regimens included carmustine, etoposide, cytarabine, cyclophosphamide and hydroxycarbamide. Ten men and 3 women aged 30–56 years with non- Hodgkin’s lymphoma (n = 8), Hodgkin’s disease (4) and acute myelocytic leukaemia (1) were included in the study. During the peritransplant period, nasal mucociliary clearance was determined daily by the nasal saccharine transit time (STT) and a mucositis score. Nasal STT was prolonged in 12/13 patients at some time during the peritransplant period and this was sustained to ≥ 30 minutes in 5/18 patients. STT was most prolonged in the 2 weeks following bone marrow transplantation and this correlated with the appearance of mucositis. One patient had an abrupt loss of nasal clearance which returned to normal within 48 hours of the last dose of total body irradiation, however, the patient subsequently developed respiratory failure and died. Author comment: ‘We observed that nasal mucociliary clearance is transiently impaired in the majority of patients undergoing BMT [bone marrow transplantation]. It is likely that ineffective clearance contributes to the impaired host defenses that put BMT patients at risk for upper respiratory tract infections.’ Sisson JH, et al. Impairment of nasal mucociliary clearance during bone marrow transplantation. Bone Marrow Transplantation 13: 631-633, May 1994 - USA 800266846 1 Reactions 4 Jun 1994 No. 504 0114-9954/10/0504-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 504 - 4 Jun 1994
Antineoplastics
Nose disorders: incidence studyNasal mucociliary clearance was found to be transiently
impaired in 92% of patients receiving antineoplastic regimensprior to undergoing bone marrow transplantation, accordingto the results of a US study. Antineoplastic regimens includedcarmustine, etoposide, cytarabine, cyclophosphamide andhydroxycarbamide.
Ten men and 3 women aged 30–56 years with non-Hodgkin’s lymphoma (n = 8), Hodgkin’s disease (4) and acutemyelocytic leukaemia (1) were included in the study. Duringthe peritransplant period, nasal mucociliary clearance wasdetermined daily by the nasal saccharine transit time (STT) anda mucositis score.
Nasal STT was prolonged in 12/13 patients at some timeduring the peritransplant period and this was sustained to ≥ 30minutes in 5/18 patients. STT was most prolonged in the 2weeks following bone marrow transplantation and thiscorrelated with the appearance of mucositis. One patient hadan abrupt loss of nasal clearance which returned to normalwithin 48 hours of the last dose of total body irradiation,however, the patient subsequently developed respiratoryfailure and died.
Author comment: ‘We observed that nasal mucociliaryclearance is transiently impaired in the majority of patientsundergoing BMT [bone marrow transplantation]. It is likely thatineffective clearance contributes to the impaired host defensesthat put BMT patients at risk for upper respiratory tractinfections.’Sisson JH, et al. Impairment of nasal mucociliary clearance during bone marrowtransplantation. Bone Marrow Transplantation 13: 631-633, May 1994 -USA 800266846
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Reactions 4 Jun 1994 No. 5040114-9954/10/0504-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
