Antineoplastics
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Reactions 469 - 18 Sep 1993 Antineoplastics Skin disorders: 2 case reports Two patients treated for colonic adenocarcinoma with an antineoplastic regimen comprising IV calcium folinate, IV fluorouracil and SC interferon alpha 2A, developed skin lesions with histologic features characteristic of graft-versus-host disease. The first patient, a 48-year-old woman, developed erythematous papules on her forehead, palm and soles, then hyperkeratosis of the palms and soles and hyperpigmentation of the forehead, 2 days after completing antineoplastic therapy. The second patient, a 47-year-old man, noted progressive pigmentation of the palms, soles, face and upper back with a burning sensation in the palms during the second course of antineoplastic therapy. With successive cycles of antineoplastic therapy there was increased palmar and plantar dysesthesia with peeling and fissuring of the skin and increased hyperpigmentation. The patient was treated with pyridoxine for suspected palmar and plantar erythrodysesthesia with some improvement. Histological examination of the skin biopsies in both patients showed apoptotic keratinocytes in the acrosyringium and the adjacent epidermis with exocytosis of mononuclear cells and focal areas of hydropic degeneration of the basal cell layer. Beard JS, et al. Combination chemotherapy with 5-fluorouracil, folinic acid, and alpha-interferon producing histologic features of graft-versus-host disease. Journal of the American Academy of Dermatology 29: 325-330, Aug 1993 - USA 800215784 1 Reactions 18 Sep 1993 No. 469 0114-9954/10/0469-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 469 - 18 Sep 1993
Antineoplastics
Skin disorders: 2 case reportsTwo patients treated for colonic adenocarcinoma with an
antineoplastic regimen comprising IV calcium folinate, IVfluorouracil and SC interferon alpha 2A, developed skin lesionswith histologic features characteristic of graft-versus-hostdisease.
The first patient, a 48-year-old woman, developederythematous papules on her forehead, palm and soles, thenhyperkeratosis of the palms and soles and hyperpigmentationof the forehead, 2 days after completing antineoplastictherapy.
The second patient, a 47-year-old man, noted progressivepigmentation of the palms, soles, face and upper back with aburning sensation in the palms during the second course ofantineoplastic therapy. With successive cycles ofantineoplastic therapy there was increased palmar and plantardysesthesia with peeling and fissuring of the skin andincreased hyperpigmentation. The patient was treated withpyridoxine for suspected palmar and plantarerythrodysesthesia with some improvement.
Histological examination of the skin biopsies in bothpatients showed apoptotic keratinocytes in the acrosyringiumand the adjacent epidermis with exocytosis of mononuclearcells and focal areas of hydropic degeneration of the basal celllayer.Beard JS, et al. Combination chemotherapy with 5-fluorouracil, folinic acid, andalpha-interferon producing histologic features of graft-versus-host disease. Journalof the American Academy of Dermatology 29: 325-330, Aug 1993 -USA 800215784
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Reactions 18 Sep 1993 No. 4690114-9954/10/0469-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
