Antineoplastics
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Reactions 454 - 5 Jun 1993 Antineoplastics Lack of association with Barrett’s oesophagus: incidence study Antineoplastic therapy is not linked with the development of Barrett’s oesophagus, according to a study of 38 patients with cancer. Barrett’s oesophagus is a rare, premalignant change in the oesophageal epithelium that usually results from gastroesphageal reflux. Some authors have suggested the condition can be caused by intensive antineoplastic therapy. The study involved 20 men (23-56 years) receiving cisplatin- based antineoplastic therapy for testicular cancer, and 18 women (33-50 years) receiving methotrexate and fluorouracil for breast cancer. Other antineoplastics included vinblastine, bleomycin, ifosfamide and etoposide in the men, and leucovorin, prednisone, doxorubicin and vincristine in the women. Barrett’s oesophagus was observed in only 1 patient in the study. However, oesophagitis was present in 5 of the women and 3 of the men, suggesting that clinicians should expect an increased incidence of oesophagitis during antineoplastic therapy Peters FTM, et al. Is chemotherapy associated with development of Barrett’s esophagus? Digestive Diseases and Sciences 38: 923-926, May 1993 - Netherlands 800201034 1 Reactions 5 Jun 1993 No. 454 0114-9954/10/0454-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 454 - 5 Jun 1993
Antineoplastics
Lack of association with Barrett’s oesophagus:incidence study
Antineoplastic therapy is not linked with the development ofBarrett’s oesophagus, according to a study of 38 patients withcancer. Barrett’s oesophagus is a rare, premalignant change inthe oesophageal epithelium that usually results fromgastroesphageal reflux. Some authors have suggested thecondition can be caused by intensive antineoplastic therapy.The study involved 20 men (23-56 years) receiving cisplatin-based antineoplastic therapy for testicular cancer, and 18women (33-50 years) receiving methotrexate and fluorouracilfor breast cancer. Other antineoplastics included vinblastine,bleomycin, ifosfamide and etoposide in the men, andleucovorin, prednisone, doxorubicin and vincristine in thewomen. Barrett’s oesophagus was observed in only 1 patientin the study. However, oesophagitis was present in 5 of thewomen and 3 of the men, suggesting that clinicians shouldexpect an increased incidence of oesophagitis duringantineoplastic therapyPeters FTM, et al. Is chemotherapy associated with development of Barrett’sesophagus? Digestive Diseases and Sciences 38: 923-926, May 1993 -Netherlands 800201034
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Reactions 5 Jun 1993 No. 4540114-9954/10/0454-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
