Antineoplastics
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Reactions 451 - 15 May 1993 S Antineoplastics Polycythaemia vera in a patient with non-Hodgkin’s lymphoma?: case report A 63-year-old man developed splenomegaly 4.5 years after completion of 3 courses of antineoplastic therapy with cyclophosphamide (total dose 15.1g), procarbazine (total dose 12.6g), vincristine and doxorubicin (CHOP). The patient’s haemoglobin, red blood cell and platelet levels were increased, as was his red cell volume. Bone marrow aspirate and biopsy showed marked erythroid hyperplasia and a diagnosis of polycythaemia vera was made. Resolution of splenomegaly and normalisation of haematological parameters occurred following phlebotomies and administration of radioactive phosphorous. Author comment: ‘We have not found any cases of polycythaemia vera (PV) following NHL (non-Hodgkin’s lymphoma) ... Although both the time period between chemotherapy administration and the appearance of PV and the high doses of alkylating agents given may suggest that the PV was a secondary and induced disorder, a coincidental association cannot be excluded.’ Bosch F, et al. Polycythaemia vera following non-Hodgkin’s lymphoma. Leukemia and Lymphoma 8: 501-502, Dec 1992 - Spain 800191478 1 Reactions 15 May 1993 No. 451 0114-9954/10/0451-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 451 - 15 May 1993
SAntineoplastics
Polycythaemia vera in a patient with non-Hodgkin’slymphoma?: case report
A 63-year-old man developed splenomegaly 4.5 years aftercompletion of 3 courses of antineoplastic therapy withcyclophosphamide (total dose 15.1g), procarbazine (total dose12.6g), vincristine and doxorubicin (CHOP). The patient’shaemoglobin, red blood cell and platelet levels were increased,as was his red cell volume. Bone marrow aspirate and biopsyshowed marked erythroid hyperplasia and a diagnosis ofpolycythaemia vera was made. Resolution of splenomegalyand normalisation of haematological parameters occurredfollowing phlebotomies and administration of radioactivephosphorous.
Author comment: ‘We have not found any cases ofpolycythaemia vera (PV) following NHL (non-Hodgkin’slymphoma) ... Although both the time period betweenchemotherapy administration and the appearance of PV andthe high doses of alkylating agents given may suggest that thePV was a secondary and induced disorder, a coincidentalassociation cannot be excluded.’Bosch F, et al. Polycythaemia vera following non-Hodgkin’s lymphoma. Leukemiaand Lymphoma 8: 501-502, Dec 1992 - Spain 800191478
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Reactions 15 May 1993 No. 4510114-9954/10/0451-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
