Antineoplastics
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Reactions 1430 - 1 Dec 2012 S Antineoplastics Various toxicities: case report A 60-year-old man developed various toxicities during treatment with docetaxel, cisplatin and gimeracil/oteracil/ tegafur [S-1] for gastric cancer. The man was diagnosed with highly advanced stage IIIB gastric cancer. Chemotherapy was commenced with IV docetaxel 40 mg/m 2 and cisplatin 60 mg/m 2 on day 1 and oral gimeracil/oteracil/tegafur 80 mg/m 2 on days 1–14, followed by a 2-week rest period. Surgery was performed after two courses. During chemotherapy, he developed grade 3 leukocytopenia and neutropenia, and grade 1 hair loss [outcomes not stated]. Ten days after surgery, the man was discharged without postoperative complications. Adjuvant chemotherapy with gimeracil/oteracil/tegafur was started, but he developed grade 3 appetite loss after one course and S-1 was therefore discontinued [outcome not stated]. Six months after surgery, peritoneal recurrence occurred and he died 2 months later. Author comment: The patient experienced a grade 3 leukocytopenia and neutropenia as adverse events of the chemotherapy. Egawa T, et al. Highly advanced gastric cancer that responded to neoadjuvant combination chemotherapy with docetaxel/CDDP/S-1 (DCS). Gan to Kagaku Ryoho 37: 2470-2472, No. 12, Nov 2010 [Japanese; summarised from a translation] - Japan 803080404 1 Reactions 1 Dec 2012 No. 1430 0114-9954/10/1430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1430 - 1 Dec 2012
SAntineoplastics
Various toxicities: case reportA 60-year-old man developed various toxicities during
treatment with docetaxel, cisplatin and gimeracil/oteracil/tegafur [S-1] for gastric cancer.
The man was diagnosed with highly advanced stage IIIBgastric cancer. Chemotherapy was commenced with IVdocetaxel 40 mg/m2 and cisplatin 60 mg/m2 on day 1 andoral gimeracil/oteracil/tegafur 80 mg/m2 on days 1–14,followed by a 2-week rest period. Surgery was performedafter two courses. During chemotherapy, he developedgrade 3 leukocytopenia and neutropenia, and grade 1 hairloss [outcomes not stated].
Ten days after surgery, the man was discharged withoutpostoperative complications. Adjuvant chemotherapy withgimeracil/oteracil/tegafur was started, but he developedgrade 3 appetite loss after one course and S-1 was thereforediscontinued [outcome not stated]. Six months aftersurgery, peritoneal recurrence occurred and he died2 months later.
Author comment: The patient experienced a grade 3leukocytopenia and neutropenia as adverse events of thechemotherapy.Egawa T, et al. Highly advanced gastric cancer that responded to neoadjuvantcombination chemotherapy with docetaxel/CDDP/S-1 (DCS). Gan to KagakuRyoho 37: 2470-2472, No. 12, Nov 2010 [Japanese; summarised from atranslation] - Japan 803080404
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Reactions 1 Dec 2012 No. 14300114-9954/10/1430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
