Antineoplastics
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Reactions 1415 - 18 Aug 2012 S Antineoplastics Parkinsonism with encephalopathy, followed by dystonia: case report A boy was diagnosed with thalamic and midbrain dysgerminoma at 16 years of age, and he developed parkinsonism with encephalopathy followed by dystonia during treatment with antineoplastics. The boy had a partial tumour resection. He received four cycles of cisplatin, cyclophosphamide, etoposide, ifosfamide and vincristine [routes and dosages not stated] followed by craniospinal radiotherapy sessions. He developed severe progressive parkinsonism with encephalopathy 2 months after the end of his treatment [age at reaction onset and duration of treatment to reaction onset not clearly stated]. The patient was given levodopa and benzatropine, but his symptoms persisted. After 8 months, improvements in his parkinsonism and encephalopathy were noted. Levodopa was weaned and withdrawn, but he developed severe progressive segmental dystonia. Levodopa was restarted, and his symptoms improved greatly. Author comment: "[This is a case] of early parkinsonism with encephalopathy followed by dystonia, which we believe was secondary to chemotherapy and/or radiation therapy." Pham MT, et al. Parkinsonism followed by dystonia in a pediatric case of midbrain tumor treatred by chemotherapy and radiotherapy: An unusual presentation Movement Disorders 27 (Suppl. 1): S434 abstr. 1319, Jun 2012. Available from: URL: http://onlinelibrary.wiley.com/doi/10.1002/mds.25051/pdf [abstract] - Canada 803075742 1 Reactions 18 Aug 2012 No. 1415 0114-9954/10/1415-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 1415 - 18 Aug 2012
SAntineoplastics
Parkinsonism with encephalopathy, followed bydystonia: case report
A boy was diagnosed with thalamic and midbraindysgerminoma at 16 years of age, and he developedparkinsonism with encephalopathy followed by dystoniaduring treatment with antineoplastics.
The boy had a partial tumour resection. He receivedfour cycles of cisplatin, cyclophosphamide, etoposide,ifosfamide and vincristine [routes and dosages not stated]followed by craniospinal radiotherapy sessions. Hedeveloped severe progressive parkinsonism withencephalopathy 2 months after the end of his treatment[age at reaction onset and duration of treatment to reactiononset not clearly stated].
The patient was given levodopa and benzatropine, buthis symptoms persisted. After 8 months, improvements inhis parkinsonism and encephalopathy were noted.Levodopa was weaned and withdrawn, but he developedsevere progressive segmental dystonia. Levodopa wasrestarted, and his symptoms improved greatly.
Author comment: "[This is a case] of early parkinsonismwith encephalopathy followed by dystonia, which we believewas secondary to chemotherapy and/or radiation therapy."Pham MT, et al. Parkinsonism followed by dystonia in a pediatric case of midbraintumor treatred by chemotherapy and radiotherapy: An unusual presentationMovement Disorders 27 (Suppl. 1): S434 abstr. 1319, Jun 2012. Available from:URL: http://onlinelibrary.wiley.com/doi/10.1002/mds.25051/pdf [abstract] -Canada 803075742
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Reactions 18 Aug 2012 No. 14150114-9954/10/1415-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
