Antineoplastics
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Reactions 1351 - 14 May 2011 S Antineoplastics Ischaemic stroke: 2 case reports A retrospective study identified two women [ages not stated] who developed an ischaemic stroke during chemotherapy with epirubicin or CMF(cyclophosphamide, methotrexate, fluorouracil) for early stage breast cancer [patient outcomes not stated]. Patient 1 started receiving IV epirubicin 100 mg/m 2 every 3 weeks. During cycle 4, she experienced an ischaemic stroke. She was hospitalised and received low-dose aspirin. Patient 2 started receiving IV epirubicin 100 mg/m 2 every 3 weeks for 4 cycles followed by CMF chemotherapy, consisting of IV cyclophosphamide 600 mg/m 2 , IV methotrexate 40 mg/m 2 and IV fluorouracil 600 mg/m 2 on day 1 and 8 every 4 weeks. During cycle 8, she experienced an ischaemic stroke. She was hospitalised and received low-dose aspirin. Nolan L, et al. The incidence of symptomatic thromboembolism in patients receiving adjuvant anthracycline-based chemotherapy for early stage breast cancer. Breast 20: 151-154, No. 2, Apr 2011. Available from: URL: http:// dx.doi.org/10.1016/j.breast.2010.09.001 - United Kingdom 803054276 1 Reactions 14 May 2011 No. 1351 0114-9954/10/1351-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1351 - 14 May 2011
SAntineoplastics
Ischaemic stroke: 2 case reportsA retrospective study identified two women [ages not
stated] who developed an ischaemic stroke duringchemotherapy with epirubicin or CMF(cyclophosphamide,methotrexate, fluorouracil) for early stage breast cancer[patient outcomes not stated].
Patient 1 started receiving IV epirubicin 100 mg/m2 every3 weeks. During cycle 4, she experienced an ischaemicstroke. She was hospitalised and received low-dose aspirin.
Patient 2 started receiving IV epirubicin 100 mg/m2 every3 weeks for 4 cycles followed by CMF chemotherapy,consisting of IV cyclophosphamide 600 mg/m2, IVmethotrexate 40 mg/m2 and IV fluorouracil 600 mg/m2 onday 1 and 8 every 4 weeks. During cycle 8, she experiencedan ischaemic stroke. She was hospitalised and receivedlow-dose aspirin.Nolan L, et al. The incidence of symptomatic thromboembolism in patientsreceiving adjuvant anthracycline-based chemotherapy for early stage breast cancer.Breast 20: 151-154, No. 2, Apr 2011. Available from: URL: http://dx.doi.org/10.1016/j.breast.2010.09.001 - United Kingdom 803054276
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Reactions 14 May 2011 No. 13510114-9954/10/1351-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
