Antineoplastics
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Reactions 1234 - 10 Jan 2009 S Antineoplastics Pneumonitis: case report A 51-year-old man with non-Hodgkin’s lymphoma received five courses of R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone [dosages not stated]. F-fluorodeoxyglucose PET (F-FDG-PET) scanning showed diffuse lung uptake, and blood gas analysis revealed hypoxia with a decrease in PaO2. No abnormalities were seen on subsequent high-resolution CT scanning. Three days later, he experienced mild dyspnoea [time to reaction onset not clearly stated]. On further scanning, patchy ground-glass opacities were present with interlobular septum thickening. In the absence of microbiological abnormalities to indicate the presence of infectious disease, drug-induced pneumonitis was diagnosed. He was commenced on high-dose steroid therapy, and after 3 weeks his symptoms and CT scan abnormalities had almost disappeared. Author comment: "The pathogenesis of drug-induced pneumonitis remains unclear and mechanisms differ among drugs; however, neutrophils are considered to play an important role." Yamane T, et al. Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin’s lymphoma. Annals of Nuclear Medicine 22: 719-722, No. 8, Oct 2008 - Japan 801135016 1 Reactions 10 Jan 2009 No. 1234 0114-9954/10/1234-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 1234 - 10 Jan 2009
SAntineoplastics
Pneumonitis: case reportA 51-year-old man with non-Hodgkin’s lymphoma received
five courses of R-CHOP: rituximab, cyclophosphamide,doxorubicin, vincristine and prednisone [dosages not stated].F-fluorodeoxyglucose PET (F-FDG-PET) scanning showeddiffuse lung uptake, and blood gas analysis revealed hypoxiawith a decrease in PaO2. No abnormalities were seen onsubsequent high-resolution CT scanning. Three days later, heexperienced mild dyspnoea [time to reaction onset not clearlystated]. On further scanning, patchy ground-glass opacitieswere present with interlobular septum thickening. In theabsence of microbiological abnormalities to indicate thepresence of infectious disease, drug-induced pneumonitis wasdiagnosed. He was commenced on high-dose steroid therapy,and after 3 weeks his symptoms and CT scan abnormalitieshad almost disappeared.
Author comment: "The pathogenesis of drug-inducedpneumonitis remains unclear and mechanisms differ amongdrugs; however, neutrophils are considered to play animportant role."Yamane T, et al. Drug-induced pneumonitis detected earlier by 18F-FDG-PET thanby high-resolution CT: a case report with non-Hodgkin’s lymphoma. Annals ofNuclear Medicine 22: 719-722, No. 8, Oct 2008 - Japan 801135016
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Reactions 10 Jan 2009 No. 12340114-9954/10/1234-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
