Antineoplastics
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Reactions 1254 - 30 May 2009 S Antineoplastics Hard palatal perforation due to mucormycosis in a child: case report An 8-year-old boy developed a mucormycosis infection leading to a hard palatal perforation, while undergoing chemotherapy treatment for acute lymphoblastic leukaemia (ALL-L1). Following his diagnosis, the boy started induction treatment with vincristine, daunorubicin, asparaginase [Leucogenase], oral prednisolone and intrathecal methotrexate (MCP-841 protocol) [dosages not stated]. He was also administered antibacterials and granulocyte macrophage colony stimulating factor for febrile neutropenia that developed after each week of therapy. Anaemia necessitated blood transfusions. During the fourth week of chemotherapy, he reported nasal pain. Examination revealed a broadening of the nasal bridge and an ulcer crater (3 × 3cm) in his hard palate with a necrotic eschar on it. A biopsy of the lesion demonstrated nonseptate mucormycotic hyphae with acute right angle branching invading blood vessels. There was also growth of mucormycosis hyphae evident in the tissue culture. The boy underwent surgical debridement of the necrotic area. He subsequently received amphotericin B liposomal, and after the infection was controlled, he was fitted with a palatal prosthesis. A palatoplasty was scheduled for a later date. At last follow-up, chemotherapy was continuing. Author comment: "The reported case was diagnosed as a case of ALL-L1 who was on prolonged chemotherapy and oral corticosteroids and hence more susceptible to mucormycosis infection." Samanta DR, et al. Hard palate perforation in acute lymphoblastic leukemia due to mucormycosis - a case report. Indian Journal of Hematology and Blood Transfusion 25: 36-39, No. 1, 2009 - India 801141686 1 Reactions 30 May 2009 No. 1254 0114-9954/10/1254-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1254 - 30 May 2009
SAntineoplastics
Hard palatal perforation due to mucormycosis ina child: case report
An 8-year-old boy developed a mucormycosis infectionleading to a hard palatal perforation, while undergoingchemotherapy treatment for acute lymphoblasticleukaemia (ALL-L1).
Following his diagnosis, the boy started inductiontreatment with vincristine, daunorubicin, asparaginase[Leucogenase], oral prednisolone and intrathecalmethotrexate (MCP-841 protocol) [dosages not stated]. Hewas also administered antibacterials and granulocytemacrophage colony stimulating factor for febrileneutropenia that developed after each week of therapy.Anaemia necessitated blood transfusions. During thefourth week of chemotherapy, he reported nasal pain.Examination revealed a broadening of the nasal bridge andan ulcer crater (3 × 3cm) in his hard palate with a necroticeschar on it. A biopsy of the lesion demonstratednonseptate mucormycotic hyphae with acute right anglebranching invading blood vessels. There was also growth ofmucormycosis hyphae evident in the tissue culture.
The boy underwent surgical debridement of the necroticarea. He subsequently received amphotericin B liposomal,and after the infection was controlled, he was fitted with apalatal prosthesis. A palatoplasty was scheduled for a laterdate. At last follow-up, chemotherapy was continuing.
Author comment: "The reported case was diagnosed as acase of ALL-L1 who was on prolonged chemotherapy and oralcorticosteroids and hence more susceptible to mucormycosisinfection."Samanta DR, et al. Hard palate perforation in acute lymphoblastic leukemia due tomucormycosis - a case report. Indian Journal of Hematology and BloodTransfusion 25: 36-39, No. 1, 2009 - India 801141686
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Reactions 30 May 2009 No. 12540114-9954/10/1254-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
