Antineoplastics
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Reactions 1357 - 25 Jun 2011 S Antineoplastics Osteoporotic greenstick fracture: case report A girl with osteosarcoma developed an osteoporotic greenstick tibial fracture while receiving adjuvant chemotherapy with methotrexate, cisplatin, doxorubicin and ifosfamide [frequencies and routes not stated; not all doses stated]. At 12 years of age, in May 2008, the girl was diagnosed with high-grade osteosarcoma. In June 2008, she commenced neoadjuvant chemotherapy with high-dose methotrexate 12 g/m 2 , cisplatin and doxorubicin under the Italian Sarcoma Group OS1 protocol. In August 2008, 3 weeks after her last cycle, she underwent tumour resection and reconstruction arthroplasty. Three weeks after surgery, she started receiving adjuvant chemotherapy with methotrexate, cisplatin, doxorubicin and ifosfamide. Eight months after surgery, while still receiving chemotherapy, she presented with acute pain in the right distal tibia. X-rays revealed a distal greenstick tibial fracture. Contrast MRI demonstrated the fracture was not a metastatic lesion. Prior to the fracture, she had received a cumulative methotrexate dose of 48 g/m 2 . The girl underwent application of a plaster cast, which was worn for 40 days. She then wore a splint for a further 4 weeks. Three months after the fracture occurred, x-ray revealed healing. She remained disease-free and in good health at 18 months after surgery. Zoccali C, et al. A greenstick osteoporotic tibial fracture while on chemotherapy in a 12-year-old girl with osteosarcoma of the knee: does a preventive role exist for agents that reduce iatrogenic bone loss and skeletal-related events?. [Review]. Journal of Biological Regulators and Homeostatic Agents 25: 131-5, No. 1, Jan- Mar 2011 - Italy 803056012 1 Reactions 25 Jun 2011 No. 1357 0114-9954/10/1357-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1357 - 25 Jun 2011
SAntineoplastics
Osteoporotic greenstick fracture: case reportA girl with osteosarcoma developed an osteoporotic
greenstick tibial fracture while receiving adjuvantchemotherapy with methotrexate, cisplatin, doxorubicinand ifosfamide [frequencies and routes not stated; not alldoses stated].
At 12 years of age, in May 2008, the girl was diagnosedwith high-grade osteosarcoma. In June 2008, shecommenced neoadjuvant chemotherapy with high-dosemethotrexate 12 g/m2, cisplatin and doxorubicin under theItalian Sarcoma Group OS1 protocol. In August 2008,3 weeks after her last cycle, she underwent tumourresection and reconstruction arthroplasty. Three weeksafter surgery, she started receiving adjuvant chemotherapywith methotrexate, cisplatin, doxorubicin and ifosfamide.Eight months after surgery, while still receivingchemotherapy, she presented with acute pain in the rightdistal tibia. X-rays revealed a distal greenstick tibial fracture.Contrast MRI demonstrated the fracture was not ametastatic lesion. Prior to the fracture, she had received acumulative methotrexate dose of 48 g/m2.
The girl underwent application of a plaster cast, whichwas worn for 40 days. She then wore a splint for a further4 weeks. Three months after the fracture occurred, x-rayrevealed healing. She remained disease-free and in goodhealth at 18 months after surgery.Zoccali C, et al. A greenstick osteoporotic tibial fracture while on chemotherapy ina 12-year-old girl with osteosarcoma of the knee: does a preventive role exist foragents that reduce iatrogenic bone loss and skeletal-related events?. [Review].Journal of Biological Regulators and Homeostatic Agents 25: 131-5, No. 1, Jan-Mar 2011 - Italy 803056012
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Reactions 25 Jun 2011 No. 13570114-9954/10/1357-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
