Antineoplastics
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Reactions 1338 - 12 Feb 2011 S Antineoplastics Blastoschizomyces infection?: 6 case reports Six patients with haematological malignancies developed Blastoschizomyces [Trichosporon] infections after chemotherapy. The patients were aged between 26 and 67 years; five were male. Patient 4 had non-Hodgkin’s lymphoma with autogenic transplant of haematopoietic progenitors, while the rest had acute myeloid leukaemia. Patient 4 received carmustine, etoposide, cytarabine and melphalan; the other five were treated with idarubicin, cytarabine and etoposide [dosage details not stated; duration of treatment to reaction onset not clearly stated]. The patients had received chemotherapy from 6 to 33 days previously. Duration of neutropenia ranged from 11 to 21 days. The most common clinical manifestations were fever, skin lesions, jaundice and shock. Despite antifungal prophylaxis, Blastoschizomyces spp. was isolated from blood and bronchoalveolar washings. Treatment consisted of amphotericin B for 4 to 18 days or voriconazole (Patient 3). Five patients died: four from invasive fungal infection and one from Klebsiella sepsis. Patient 2, who received the longest course of amphotericin B therapy, was cured. Batlle M, et al. Outbreak of Blastoschizomyces spp. infection in a haematology unit: Study of 6 cases and finding of the source of infection. Medicina Clinica 135: 672-674, No. 14, 13 Nov 2010. Available from: URL: http://dx.doi.org/10.1016/ j.medcli.2009.03.030 [Spanish; summarised from a translation] - Spain 803049174 1 Reactions 12 Feb 2011 No. 1338 0114-9954/10/1338-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1338 - 12 Feb 2011
SAntineoplastics
Blastoschizomyces infection?: 6 case reportsSix patients with haematological malignancies developed
Blastoschizomyces [Trichosporon] infections afterchemotherapy.
The patients were aged between 26 and 67 years; fivewere male. Patient 4 had non-Hodgkin’s lymphoma withautogenic transplant of haematopoietic progenitors, whilethe rest had acute myeloid leukaemia. Patient 4 receivedcarmustine, etoposide, cytarabine and melphalan; theother five were treated with idarubicin, cytarabine andetoposide [dosage details not stated; duration of treatmentto reaction onset not clearly stated]. The patients hadreceived chemotherapy from 6 to 33 days previously.Duration of neutropenia ranged from 11 to 21 days. Themost common clinical manifestations were fever, skinlesions, jaundice and shock. Despite antifungalprophylaxis, Blastoschizomyces spp. was isolated fromblood and bronchoalveolar washings.
Treatment consisted of amphotericin B for 4 to 18 daysor voriconazole (Patient 3). Five patients died: four frominvasive fungal infection and one from Klebsiella sepsis.Patient 2, who received the longest course ofamphotericin B therapy, was cured.Batlle M, et al. Outbreak of Blastoschizomyces spp. infection in a haematologyunit: Study of 6 cases and finding of the source of infection. Medicina Clinica 135:672-674, No. 14, 13 Nov 2010. Available from: URL: http://dx.doi.org/10.1016/j.medcli.2009.03.030 [Spanish; summarised from a translation] -Spain 803049174
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Reactions 12 Feb 2011 No. 13380114-9954/10/1338-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
