Antineoplastics
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Reactions 1124 - 21 Oct 2006 ★ Antineoplastics Telangiectasia (first report with bleomycin, doxorubicin and vinblastine): case report A 31-year-old man began receiving antineoplastic therapy with doxorubicin, bleomycin, vinblastine and dacarbazine * [dosages not stated] for Hodgkin’s disease. After a few days, he started to develop lesions. After about 3 months, he presented with a 2-month history of a slightly erythematous, progressive, asymptomatic eruption on his left upper chest. A physical examination showed multiple macular stellate telangiectasias on his left dermatomal area of T6, along Blaschko’s lines. He was diagnosed with unilateral naevoid telangiectasia. Histopathological analysis revealed numerous dilated vessels in his upper and middle dermis. [Patient outcome not stated.] Author comment: "[W]e propose a previously unreported aetiology involving a combination of chemotherapy and individual host factors. The precise mechanism is unclear, but a mere coincidence cannot be ruled out." * It was confirmed by personal communication with the author that the patient received dacarbazine. Rodr ´ ıguez-Mart ´ ın M, et al. Unilateral naevoid telangiectasia in a young man after chemotherapy: a simple coincidence or a new clinical association? Journal of the European Academy of Dermatology and Venereology 20: 1001-1002, No. 8, Sep 2006 - Spain 801047327 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of telangiectasia associated with bleomycin, doxorubicin or vinblastine. The WHO Adverse Drug Reactions database contained no reports of telangiectasis associated with bleomycin, doxorubicin or vinblastine. 1 Reactions 21 Oct 2006 No. 1124 0114-9954/10/1124-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 1124 - 21 Oct 2006
★Antineoplastics
Telangiectasia (first report with bleomycin,doxorubicin and vinblastine): case report
A 31-year-old man began receiving antineoplastic therapywith doxorubicin, bleomycin, vinblastine and dacarbazine*
[dosages not stated] for Hodgkin’s disease. After a few days, hestarted to develop lesions. After about 3 months, he presentedwith a 2-month history of a slightly erythematous, progressive,asymptomatic eruption on his left upper chest. A physicalexamination showed multiple macular stellate telangiectasiason his left dermatomal area of T6, along Blaschko’s lines. Hewas diagnosed with unilateral naevoid telangiectasia.Histopathological analysis revealed numerous dilated vesselsin his upper and middle dermis. [Patient outcome not stated.]
Author comment: "[W]e propose a previously unreportedaetiology involving a combination of chemotherapy andindividual host factors. The precise mechanism is unclear, buta mere coincidence cannot be ruled out."
* It was confirmed by personal communication with the author thatthe patient received dacarbazine.
Rodrı́guez-Martı́n M, et al. Unilateral naevoid telangiectasia in a young man afterchemotherapy: a simple coincidence or a new clinical association? Journal of theEuropean Academy of Dermatology and Venereology 20: 1001-1002, No. 8, Sep2006 - Spain 801047327
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of telangiectasia associatedwith bleomycin, doxorubicin or vinblastine. The WHO AdverseDrug Reactions database contained no reports of telangiectasisassociated with bleomycin, doxorubicin or vinblastine.
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Reactions 21 Oct 2006 No. 11240114-9954/10/1124-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
