Antineoplastics
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Reactions 1239 - 14 Feb 2009 Antineoplastics Neuroimaging abnormalities: case report A 39-year-old woman with medulloblastoma, underwent partial resection of a vermian mass. She then received intensive-dose sequential chemotherapy [specific drugs, dosages and duration of therapy not stated], craniospinal axis hyperfractionated accelerated radiotherapy, two cycles of high-dose chemotherapy consisting of thiotepa and thiotepa/carboplatin [dosages and duration of therapy not stated], and stem cell transplantation. A subsequent MRI showed no signs of disease or therapy-related changes. However, 4 months later, multiple gadolinium enhancing lesions on T1-weighted images in the white matter region of the cerebellum were observed. The enhancement was nodular and no mass effect was evident. Although suggestive of recurrent disease, she was without symptoms. A ’wait-and-see’ policy was adopted; 15 months after their appearance, the brain abnormalities began to regress. Author comment: "[C]onfounding brain MRI findings can. . . be observed in adult patients treated with aggressive treatment strategies, including radiotherapy and myeloablative chemotherapy, for brain tumours." Secondino S, et al. Neuroimaging abnormalities in adult medulloblastoma undergoing intensified therapy. Anticancer Research 28: 3991-3992, No. 6, Nov- Dec 2008 - Italy 801136426 1 Reactions 14 Feb 2009 No. 1239 0114-9954/10/1239-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1239 - 14 Feb 2009
Antineoplastics
Neuroimaging abnormalities: case reportA 39-year-old woman with medulloblastoma, underwent
partial resection of a vermian mass. She then receivedintensive-dose sequential chemotherapy [specific drugs,dosages and duration of therapy not stated], craniospinalaxis hyperfractionated accelerated radiotherapy, two cyclesof high-dose chemotherapy consisting of thiotepa andthiotepa/carboplatin [dosages and duration of therapy notstated], and stem cell transplantation. A subsequent MRIshowed no signs of disease or therapy-related changes.However, 4 months later, multiple gadolinium enhancinglesions on T1-weighted images in the white matter regionof the cerebellum were observed. The enhancement wasnodular and no mass effect was evident. Althoughsuggestive of recurrent disease, she was withoutsymptoms. A ’wait-and-see’ policy was adopted;15 months after their appearance, the brain abnormalitiesbegan to regress.
Author comment: "[C]onfounding brain MRI findingscan. . . be observed in adult patients treated with aggressivetreatment strategies, including radiotherapy andmyeloablative chemotherapy, for brain tumours."Secondino S, et al. Neuroimaging abnormalities in adult medulloblastomaundergoing intensified therapy. Anticancer Research 28: 3991-3992, No. 6, Nov-Dec 2008 - Italy 801136426
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Reactions 14 Feb 2009 No. 12390114-9954/10/1239-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
